Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
Epilepsy Behav. 2010 Mar;17(3):402-7. doi: 10.1016/j.yebeh.2010.01.009. Epub 2010 Feb 10.
In this study the relationship between language skill and frontotemporal volumes was compared in 69 medically treated subjects with epilepsy and 34 healthy children, aged 6.1-16.6 years. Also, whether patients with linguistic deficits had abnormal volumes and atypical associations between volumes and language skills in these brain regions was determined. The children underwent language testing and MRI scans at 1.5 T. Brain tissue was segmented and frontotemporal volumes were computed. Higher mean language scores were significantly associated with larger inferior frontal gyrus, temporal lobe, and posterior superior temporal gyrus gray matter volumes in the epilepsy group and in the children with epilepsy with average language scores. Increased total brain and dorsolateral prefrontal gray and white matter volumes, however, were associated with higher language scores in the healthy controls. Within the epilepsy group, linguistic deficits were related to smaller anterior superior temporal gyrus gray matter volumes and there was a negative association between language scores and dorsolateral prefrontal gray matter volumes. These findings demonstrate abnormal development of language-related brain regions, and imply differential reorganization of brain regions subserving language in children with epilepsy with normal linguistic skills and in those with impaired language.
在这项研究中，我们比较了 69 名接受医学治疗的癫痫患者和 34 名健康儿童（年龄 6.1-16.6 岁）的语言技能与额颞叶体积之间的关系。此外，我们还确定了是否存在语言缺陷的患者在这些脑区的体积异常和体积与语言技能之间的非典型关联。这些儿童在 1.5T 磁共振扫描仪上接受了语言测试和 MRI 扫描。对脑组织进行分割并计算额颞叶体积。在癫痫组和平均语言评分正常的癫痫患儿中，较高的平均语言评分与较低的额下回、颞叶和后上颞叶灰质体积显著相关。然而，在健康对照组中，总脑和背外侧前额叶灰质和白质体积的增加与较高的语言评分相关。在癫痫组中，语言缺陷与前上颞叶灰质体积较小有关，并且语言评分与背外侧前额叶灰质体积之间存在负相关。这些发现表明与语言相关的脑区发育异常，并暗示在具有正常语言技能的癫痫儿童和语言受损的癫痫儿童中，语言相关脑区的重新组织存在差异。
