Centro de Investigacion Biomedica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Centro, 62790, Xochitepec, Morelos, Mexico.
J Ethnopharmacol. 2010 Apr 21;128(3):611-4. doi: 10.1016/j.jep.2010.01.059. Epub 2010 Feb 10.
Citrus limetta Risso (Rutaceae) is widely used in Mexico for healing purposes, among them as antihypertensive treatment.
To assess the antihypertensive effect of C. limetta leaves as one of its ethnomedical uses.
The acute response of blood pressure to angiotensin II administration was measured in mice. Additionally, the acute oral toxicity profiles were determined.
The findings of the current investigation showed that different concentrations of the aqueous extract prevented the raise of systolic blood pressure (p< or =0.001 vs. vehicle), diastolic blood pressure (p< or =0.0002 vs. vehicle) and mean blood pressure (p< or =0.0000 vs. vehicle); with a dose dependent effect for diastolic pressures at 125-500mg/kg dosages. The 500 and 1000mg/kg doses inhibited the action of Ang II in similar extent to telmisartan. Toxic signs or deaths were not observed in mice treated at 2000mg/kg of C. limetta extract.
All doses of C. limetta aqueous extract, used in this assay, were safe and effective.
芸香科柑橘属莱姆（Rutaceae）在墨西哥被广泛用于治疗，包括作为抗高血压治疗。
评估莱姆叶作为其传统医学用途之一的抗高血压作用。
在小鼠中测量血管紧张素 II 给药的急性血压反应。此外，还确定了急性口服毒性特征。
本研究的结果表明，不同浓度的水提取物可预防收缩压升高（p<或=0.001 与载体相比）、舒张压升高（p<或=0.0002 与载体相比）和平均血压升高（p<或=0.0000 与载体相比）；在 125-500mg/kg 剂量下，舒张压呈剂量依赖性。500 和 1000mg/kg 剂量与替米沙坦相似地抑制了 Ang II 的作用。在 2000mg/kg 的莱姆提取物治疗的小鼠中未观察到毒性体征或死亡。
在本试验中使用的莱姆水提取物的所有剂量均安全有效。
