Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran ; Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2015 Feb;18(2):153-8.
Auraptene, a monoterpene coumarin from Citrus species, exhibits cardioprotective effects. In this study, the effects of auraptene administration were investigated on blood pressure of normotensive and desoxycorticosterone acetate (DOCA) salt induced hypertensive rats.
Five weeks administration of auraptene (2, 4, 8 and 16 mg/kg/day) and nifedipine (0.25, 0.5, 1, 2 and 4 mg/kg/day) in different groups of normotensive and hypertensive rats (at the end of 3 weeks treatment by DOCA salt) was carried out and their effects on mean systolic blood pressure (MSBP) and mean heart rate (MHR) were evaluated using tail cuff method.
Our results indicated that chronic administration of auraptene (2, 4, 8 and 16 mg/kg/day) significantly reduced the MSBP in DOCA salt treated rats in a dose and time dependent manner. The percent of decreases in MSBP levels by the highest dose of auraptene (16 mg/kg) at the end of 4 (th) to 8 (th) weeks, were 7.00%, 10.78%, 16.07%, 21.28% and 27.54% respectively (P<0.001). Moreover the antihypertensive effect of auraptene was less than nifedipine (ED50 value of nifedipine = 0.7 mg/kg at 8(th) week and ED50 value of auraptene = 5.64 mg/kg at 8 week).
Auraptene considerably reduced MSBP in hypertensive rats, but not in normotensive (normal saline treated) rats. The results of MHR measurement showed that the increase in MHR was not significant in comparison with DOCA treated rats.
柠檬苦素是一种来自柑橘属植物的单萜香豆素，具有心脏保护作用。在这项研究中，研究了柠檬苦素给药对正常血压和去氧皮质酮醋酸盐（DOCA）盐诱导的高血压大鼠血压的影响。
在不同的正常血压和高血压大鼠组中（在 DOCA 盐治疗 3 周结束时），给予柠檬苦素（2、4、8 和 16 mg/kg/天）和硝苯地平（0.25、0.5、1、2 和 4 mg/kg/天）5 周，并使用尾套法评估它们对平均收缩压（MSBP）和平均心率（MHR）的影响。
我们的结果表明，柠檬苦素（2、4、8 和 16 mg/kg/天）的慢性给药以剂量和时间依赖的方式显著降低 DOCA 盐处理大鼠的 MSBP。在第 4 周到第 8 周结束时，最高剂量（16 mg/kg）的柠檬苦素降低 MSBP 水平的百分比分别为 7.00%、10.78%、16.07%、21.28%和 27.54%（P<0.001）。此外，柠檬苦素的降压作用小于硝苯地平（硝苯地平的 ED50 值在第 8 周为 0.7 mg/kg，而柠檬苦素的 ED50 值在第 8 周为 5.64 mg/kg）。
柠檬苦素可显著降低高血压大鼠的 MSBP，但对正常血压（生理盐水处理）大鼠无影响。MHR 测量结果表明，与 DOCA 处理大鼠相比，MHR 的增加并不显著。
