North East England Stem Cell Institute, Central Parkway, Newcastle upon Tyne NE13BZ, UK.
Drug Discov Today. 2010 Apr;15(7-8):306-13. doi: 10.1016/j.drudis.2010.02.001. Epub 2010 Feb 10.
Transparency of the cornea on the front surface of the eye is essential for vision. A variety of blinding ocular surface diseases involve the cornea. This review focusses on vision loss caused by disruption of the integrity and function of the outermost corneal layer (the epithelium) and the stem-cell-based therapeutic strategies in use and under development to restore sight in affected patients.
眼球前表面角膜的透明度对视力至关重要。各种致盲性眼表面疾病都涉及角膜。本综述重点介绍了由于最外层角膜层（上皮）完整性和功能的破坏以及正在使用和开发中的基于干细胞的治疗策略导致的视力丧失，以恢复受影响患者的视力。
