Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, New Delhi, India.
Autoimmun Rev. 2010 May;9(7):516-20. doi: 10.1016/j.autrev.2010.02.013. Epub 2010 Feb 8.
Vitiligo is a disorder with complex causes and is a type of autoimmune disease in which the immune system targets the body's own pigment cells and tissues. Our aim is to present an overall view of the current remedies widely adopted for the treatment of vitiligo. Medical treatments target the immune system, and try to reverse the destruction. The goal is to restore the skin's color by restoring healthy melanocytes to the affected area. Apart from melanocytes, vitiligo autoantigens appear also on other cells. Even though antibodies to pigment cells are not an agent of vitiligo, the most valuable contribution is that anti-melanocyte antibody reactivity can help in identifying relevant antigens. T cells from vitiligo skin are highly reactive towards melanoma cells and serve as an effective source to treat melanoma and stays as a solution for vitiligo. There have been many treatments to cure vitiligo such as use of steroid creams, PUVA (psoralen and ultraviolet A light), narrow band UVB (ultraviolet B), various surgical techniques, vitamin D analogues and pseudocatalase. These treatments are subjected for undesired side effects whereas some herbal and natural treatments act against the immune system with no side effects.
白癜风是一种病因复杂的疾病，属于自身免疫性疾病，免疫系统会攻击身体自身的色素细胞和组织。我们旨在全面介绍目前广泛用于治疗白癜风的各种方法。医学治疗针对免疫系统，试图逆转破坏。目标是通过将健康的黑色素细胞恢复到受影响的区域来恢复皮肤的颜色。除了黑色素细胞外，白癜风自身抗原似乎也出现在其他细胞上。尽管针对色素细胞的抗体不是白癜风的致病因素，但最有价值的贡献是抗黑色素细胞抗体反应性有助于识别相关抗原。白癜风皮肤中的 T 细胞对黑色素瘤细胞具有高度反应性，是治疗黑色素瘤的有效来源，也是白癜风的一种解决方案。有许多治疗白癜风的方法，如使用类固醇乳膏、PUVA（补骨脂素和紫外线 A 光）、窄带 UVB（紫外线 B）、各种手术技术、维生素 D 类似物和假过氧化氢酶。这些治疗方法会产生不良副作用，而一些草药和天然疗法则针对免疫系统，没有副作用。
