Department of Ophthalmology, Taipei Medical University, Taipei, Taiwan.
Stroke. 2010 Apr;41(4):613-7. doi: 10.1161/STROKEAHA.109.571000. Epub 2010 Feb 11.
Using a nationwide population-based data set from Taiwan, this study investigated the relationship between neovascular age-related macular degeneration (AMD) and the risk of stroke over a 5-year period.
The study cohort comprised 209 patients who received treatment for AMD between 1999 and 2001. We randomly selected 1045 subjects matched with the study cohort in terms of age and gender for comparison. Cox proportional hazard regressions were performed to compare the 5-year stroke-free survival rate.
Among the sampled patients, 142 patients (11.3%) had strokes during the 5-year follow-up period, 38 (18.2% of the patients with AMD) from the study cohort and 104 (9.9% of patients in the comparison cohort) from the comparison cohort. After adjusting for the patient's age, gender, monthly income, level of urbanization, and the geographic region of the community in which the patient resided and comorbidities, the hazard ratio for stroke during the follow-up period was 2.01 (P=0.001) times greater for patients with AMD than for patients without AMD. The adjusted hazard ratio for stroke during the follow-up period was 2.21 (P=0.001) times higher for patients with AMD > or = 65 years old compared with the same age group in the comparison cohort. However, no significant difference was observed in the risk of stroke between patients with AMD <65 years of age and comparison patients in the same age group.
We conclude that neovascular AMD is associated with a higher risk of stroke for patients with AMD > or = 65 years old.
本研究利用来自台湾的全国性人口基础数据，调查了 5 年内新生血管性年龄相关性黄斑变性（AMD）与中风风险之间的关系。
研究队列包括 1999 年至 2001 年间接受 AMD 治疗的 209 例患者。我们随机选择了 1045 名与研究队列在年龄和性别方面相匹配的患者作为对照。采用 Cox 比例风险回归比较 5 年无中风生存率。
在抽样患者中，142 例（11.3%）在 5 年随访期间发生中风，其中 38 例（AMD 患者的 18.2%）来自研究队列，104 例（对照队列的 9.9%）来自对照队列。在调整了患者年龄、性别、月收入、城市化水平、患者居住社区的地理位置和合并症后，AMD 患者在随访期间发生中风的风险比为 2.01（P=0.001）倍，高于无 AMD 患者。调整后，AMD 患者年龄≥65 岁的中风风险比对照队列中同年龄组高 2.21 倍（P=0.001）。然而，年龄<65 岁的 AMD 患者与同年龄组的对照患者之间的中风风险无显著差异。
我们的结论是，新生血管性 AMD 与年龄≥65 岁的 AMD 患者中风风险增加相关。
