Wang Jie, Xue Yangjing, Thapa Saroj, Wang Luping, Tang Jifei, Ji Kangting
Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Xueyuanxi Road, No. 109, Wenzhou, Zhejiang 325000, China.
Biomed Res Int. 2016;2016:8212063. doi: 10.1155/2016/8212063. Epub 2016 Dec 14.
Data on the association between age-related macular degeneration (AMD) and cardiovascular disease and mortality are conflicting. The purpose of this report is to conduct a systematic review to better understand the role of AMD as a risk factor for CVD events and mortality. We searched Medline (Ovid) and Embase (Ovid) for trials published from 1980 to 2015. We included 20 cohort studies that reported relative risks with 95% confidence intervals for the association of AMD and cardiovascular events and mortality, involving 29,964,334 participants. In a random-effects model, the adjusted RR (95% confidence interval [CI]) associated with AMD was 1.08 (1.00-1.117) for all-cause mortality (8 studies) and 1.18 (0.98-1.43) for cardiovascular disease mortality (5 studies). The pooled RR (95% CI) was 1.17 (0.94-1.45) for coronary heart disease (CHD; 3 studies) and 1.13 (0.93-1.36) for stroke (8 studies). Findings from this systematic review support that AMD is associated with increased risk of all-cause mortality. The evidence that AMD predicts incident CVD events or CVD mortality remains inclusive and warrants further study in the future.
年龄相关性黄斑变性（AMD）与心血管疾病及死亡率之间关联的数据存在矛盾。本报告的目的是进行一项系统综述，以更好地了解AMD作为心血管疾病（CVD）事件和死亡率风险因素的作用。我们检索了1980年至2015年发表在Medline（Ovid）和Embase（Ovid）上的试验。我们纳入了20项队列研究，这些研究报告了AMD与心血管事件及死亡率关联的相对风险，并给出了95%置信区间，涉及29,964,334名参与者。在随机效应模型中，与AMD相关的全因死亡率调整后相对风险（RR）（95%置信区间[CI]）为1.08（1.00 - 1.117）（8项研究），心血管疾病死亡率调整后RR为1.18（0.98 - 1.43）（5项研究）。冠心病（CHD）的合并RR（95%CI）为1.17（0.94 - 1.45）（3项研究），中风的合并RR为1.13（0.93 - 1.36）（8项研究）。该系统综述的结果支持AMD与全因死亡率风险增加相关。AMD预测新发CVD事件或CVD死亡率的证据仍不明确，未来需要进一步研究。
