Metabolic Research Centre, School of Medicine and Pharmacology, University of Western Australia, Perth, Australia.
Arterioscler Thromb Vasc Biol. 2010 May;30(5):1043-50. doi: 10.1161/ATVBAHA.109.202275. Epub 2010 Feb 11.
To examine the association between liver fat content and very low-density lipoprotein (VLDL)-apolipoprotein (apo) B-100 kinetics and the corresponding responses to weight loss in obese subjects.
VLDL-apoB-100 kinetics were assessed using stable isotope tracers, and the fat content of the liver and abdomen was determined by magnetic resonance techniques in 25 obese subjects. In univariate analysis, liver fat content was significantly (P<0.05 in all) associated with body mass index (r=0.65), visceral fat area (r=0.45), triglycerides (r=0.40), homeostasis model assessment score (r=0.40), VLDL-apoB-100 concentrations (r=0.44), and secretion rate (r=0.45). However, liver fat content was not associated with plasma concentrations of retinol-binding protein 4, fetuin A, adiponectin, interleukin-6, and tumor necrosis factor-alpha. Of these 25 subjects, 9 diagnosed as having nonalcoholic fatty liver disease (which is highly prevalent in obese individuals and strongly associated with dyslipidemia) underwent a weight loss program. The low-fat diet achieved significant reduction in body weight, body mass index, liver fat, visceral and subcutaneous fat areas, homeostasis model assessment score, triglycerides, VLDL-apoB-100 concentrations, and VLDL-apoB-100 secretion rate. The percentage reduction of liver fat with weight loss was significantly associated with the corresponding decreases in VLDL-apoB-100 secretion (r=0.67) and visceral fat (r=0.84).
In patients with obesity, hepatic steatosis increases VLDL-apoB-100 secretion. Weight loss can help reduce this abnormality.
研究肥胖患者肝内脂肪含量与极低密度脂蛋白（VLDL）-载脂蛋白 B-100 动力学之间的关系，并探讨其与体重减轻的对应关系。
采用稳定同位素示踪技术评估 VLDL-载脂蛋白 B-100 动力学，采用磁共振技术检测 25 例肥胖患者的肝内和腹部脂肪含量。单因素分析显示，肝内脂肪含量与体重指数（r=0.65，P<0.05）、内脏脂肪面积（r=0.45）、甘油三酯（r=0.40）、稳态模型评估评分（r=0.40）、VLDL-载脂蛋白 B-100 浓度（r=0.44）和分泌率（r=0.45）均显著相关（P<0.05）。然而，肝内脂肪含量与视黄醇结合蛋白 4、胎球蛋白 A、脂联素、白细胞介素 6 和肿瘤坏死因子-α的血浆浓度无关。在这 25 名患者中，有 9 名被诊断为非酒精性脂肪性肝病（在肥胖人群中发病率很高，与血脂异常密切相关），并接受了减肥计划。低脂饮食显著降低了体重、体重指数、肝内脂肪、内脏和皮下脂肪面积、稳态模型评估评分、甘油三酯、VLDL-载脂蛋白 B-100 浓度和 VLDL-载脂蛋白 B-100 分泌率。体重减轻时肝内脂肪的百分比降低与 VLDL-载脂蛋白 B-100 分泌（r=0.67）和内脏脂肪（r=0.84）的相应降低显著相关。
在肥胖患者中，肝脂肪变性增加了 VLDL-载脂蛋白 B-100 的分泌。体重减轻有助于减少这种异常。
