成年早期的脂蛋白水平与中年非酒精性脂肪性肝病：青年成人冠状动脉风险发展（CARDIA）研究
Lipoprotein Levels in Early Adulthood and NAFLD in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.
作者信息
Khanna Sahil, Wilkins John T, Ning Hongyan, Allen Norrina B, Lewis Cora E, Carr J Jeffrey, Lloyd-Jones Donald, VanWagner Lisa B
机构信息
Division of Gastroenterology & Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
出版信息
J Nutr Metab. 2022 Apr 14;2022:1727711. doi: 10.1155/2022/1727711. eCollection 2022.
OBJECTIVE
We evaluated the association of apolipoprotein B (apoB) with low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and triglycerides (TG) in early adulthood with concordant/discordant associations and midlife NAFLD.
METHODS
Participants from the CARDIA study were included ( = 2,655; baseline mean age: 25.0, 59.1% female, and 48.6% black). NAFLD was defined as liver attenuation ≤40 Hounsfield units after excluding other causes of liver fat. Logistic regression models assessed the odds of Y25 NAFLD among tertiles of apoB, LDL-C, non-HDL-C, and TG and quartiles of the apoB/TG ratio. Discordance/concordance analyses examined the association of apoB with each lipid marker and Y25 NAFLD.
RESULTS
The Y25 NAFLD prevalence was 10%. The high-tertile TG group (OR 1.87, 95% CI, and 1.30-2.69) and the low- (OR 1.98, 95% CI, and 1.30-3.01) and middle-apoB/TG ratio groups (OR 1.78, 95% CI, and 1.17-2.72) had the greatest odds of midlife NAFLD. Using discordance/concordance analysis, the high-apoB/high-TG group had the highest odds of NAFLD (OR 1.69, 95% CI, and 1.09-2.61) followed by the low-apoB/high-TG group. The high apoB/low TG group had the lowest odds of NAFLD.
CONCLUSIONS
Among the studied lipid markers in early adulthood, TG levels have the strongest and most consistent association with midlife NAFLD.
目的
我们评估了成年早期载脂蛋白B（apoB）与低密度脂蛋白胆固醇（LDL-C）、非高密度脂蛋白胆固醇（non-HDL-C）以及甘油三酯（TG）之间的关联，以及这些关联的一致性/不一致性与中年非酒精性脂肪性肝病（NAFLD）的关系。
方法
纳入了来自CARDIA研究的参与者（n = 2655；基线平均年龄：25.0岁，59.1%为女性，48.6%为黑人）。NAFLD被定义为在排除其他肝脏脂肪原因后肝脏衰减≤40亨氏单位。逻辑回归模型评估了apoB、LDL-C、non-HDL-C和TG三分位数以及apoB/TG比值四分位数中Y25时NAFLD的患病几率。不一致性/一致性分析检查了apoB与每种脂质标志物以及Y25时NAFLD之间的关联。
结果
Y25时NAFLD患病率为10%。高三分位TG组（比值比[OR] 1.87，95%置信区间[CI]为1.30 - 2.69）以及低（OR 1.98，95% CI为1.30 - 3.01）和中apoB/TG比值组（OR 1.78，95% CI为1.17 - 2.72）中年患NAFLD的几率最高。使用不一致性/一致性分析，高apoB/高TG组患NAFLD的几率最高（OR 1.69，95% CI为1.09 - 2.61），其次是低apoB/高TG组。高apoB/低TG组患NAFLD的几率最低。
结论
在成年早期研究的脂质标志物中，TG水平与中年NAFLD的关联最强且最一致。
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