Mackelvie Kerry J, Meneilly Graydon S, Elahi Dariush, Wong Alfred C K, Barr Susan I, Chanoine Jean-Pierre
Endocrinology and Diabetes Unit, Room K4-212, British Columbia's Children's Hospital, 4480 Oak Street, Vancouver, British Columbia, Canada V6H 3V4.
J Clin Endocrinol Metab. 2007 Feb;92(2):648-54. doi: 10.1210/jc.2006-1028. Epub 2006 Nov 21.
Increased physical activity is an integral part of weight loss programs in adolescents. We hypothesized that exercise could affect appetite-regulating hormones and the subjective desire to eat, which could partly explain the poor success rate of the existing interventions.
The objective of this study was to investigate prospectively the effects of exercise on acylated ghrelin (AG) and desacyl ghrelin (DG) concentrations and on appetite.
The setting for this study was a tertiary care center.
Normal-weight [NW; body mass index (mean +/- se), 20.7 +/- 0.5 kg/m2] and overweight (OW; body mass index, 32.4 +/- 1.7) male adolescents (n = 17/group, age 15.3 +/- 0.2 yr) were studied.
Those studied participated in 5 consecutive days of aerobic exercise (1 h/d).
Changes in AG and DG concentrations and in appetite during a test meal were studied.
Exercise did not significantly affect insulin sensitivity or body weight. Fasting total (AG and DG) ghrelin concentrations were lower in OW (600 +/- 33 pg/ml) compared with NW (764 +/- 33 pg/ml, P < 0.05) boys and were not affected by exercise. In contrast, there was a differential effect of exercise on both AG and DG (P <or= 0.019). AG significantly increased after exercise, and this increase was greater in NW compared with OW adolescents (P < 0.05). Higher AG concentrations were correlated with an increase in markers of appetite (P < 0.05).
Exercise differentially affects AG and DG in NW and OW male adolescents. Our data suggest that total ghrelin does not adequately reflect AG and DG concentrations and that the influence of exercise-induced hormonal changes should be considered to ensure success in weight management.
增加体力活动是青少年减肥计划的一个重要组成部分。我们推测运动可能会影响食欲调节激素和主观进食欲望，这可能部分解释了现有干预措施成功率较低的原因。
本研究的目的是前瞻性地研究运动对酰基化胃饥饿素（AG）和去酰基化胃饥饿素（DG）浓度以及食欲的影响。
本研究的地点是一家三级医疗中心。
研究了正常体重[NW；体重指数（均值±标准误），20.7±0.5kg/m²]和超重（OW；体重指数，32.4±1.7）的男性青少年（每组n = 17，年龄15.3±0.2岁）。
研究对象连续5天参加有氧运动（每天1小时）。
研究了测试餐期间AG和DG浓度以及食欲的变化。
运动对胰岛素敏感性或体重没有显著影响。与NW男孩（764±33pg/ml，P<0.05）相比，OW男孩（600±33pg/ml）的空腹总（AG和DG）胃饥饿素浓度较低，且不受运动影响。相比之下，运动对AG和DG均有不同的影响（P≤0.019）。运动后AG显著增加，且NW青少年的增加幅度大于OW青少年（P<0.05）。较高的AG浓度与食欲指标的增加相关（P<0.05）。
运动对NW和OW男性青少年的AG和DG有不同影响。我们的数据表明，总胃饥饿素不能充分反映AG和DG的浓度，应考虑运动引起的激素变化的影响，以确保体重管理的成功。
