Laboratory of Microbiology and Oncology, Sojo University, 22-1, Ikeda 4-chome, Kumamoto 860-0082, Japan.
Anticancer Res. 2010 Jan;30(1):111-8.
Kumaizasa bamboo found in Hokkaido is used for traditional medicine in Japan. The cancer preventive effect of vigorous (multistep) hot water extract of Kumaizasa was examined in relation to immunological conditioning and free radical scavenging activity.
Cytokine induction in mice, free radical scavenging activity in vitro, and cancer preventive effect by oral administration of the vigorous extracts prior to tumor implantation or carcinogenesis by 7,12-dimethylbenz[a]anthracene (DMBA) were examined.
In tumor inoculated mouse models (S-180 sarcoma, Meth-A fibrosarcoma, B16-F10 melanoma), the vigorous extracts from Kumaizasa bamboo leaves suppressed tumor growth and prolonged survival significantly. In the chemical carcinogenesis model suppression of cancer incidence on day 100, tumor size and survival time were significantly improved with the vigorous extract, at/or above 0.03% in the diet, when given two weeks prior to the administration of the carcinogen.
The vigorous extracts of bamboo leaf show immunopotentiating and radical scavenging effects and administration prior to carcinogen exposure or tumor inoculation significantly suppresses tumor incidence and tumor growth and prolongs survival.
北海道产熊笹竹在日本被用于传统医药。本研究探讨了熊笹竹叶强烈（多步）热水提取物的抗癌作用与其免疫调节和自由基清除活性之间的关系。
检测了熊笹竹叶强烈提取物对小鼠细胞因子诱导、体外自由基清除活性以及肿瘤植入或二甲基苯并蒽（DMBA）致癌前口服给药的抗癌作用。
在肿瘤接种小鼠模型（S-180 肉瘤、Meth-A 纤维肉瘤、B16-F10 黑色素瘤）中，熊笹竹叶的强烈提取物显著抑制肿瘤生长并延长存活时间。在化学致癌模型中，在致癌物给药前两周给予饮食中 0.03%或以上的强烈提取物可显著抑制第 100 天的癌症发生率、肿瘤大小和存活时间。
竹叶强烈提取物具有免疫增强和自由基清除作用，在致癌物暴露或肿瘤接种前给药可显著抑制肿瘤发生率、肿瘤生长并延长存活时间。
