Department of Haematology, Iatriko Athinon, Psychicon Branch, 1st Kyriakidou Str, P. Psychikon, 15452 Athens, Greece.
Anticancer Res. 2010 Jan;30(1):271-6.
Primary effusion lymphoma (PEL) is a rare non-Hodgkin's lymphoma (NHL) mostly occurring in HIV-positive patients. It is characterized by the development of effusion in one or more body cavities, with no tumor masses and a positive human herpes virus-8 (HHV8) status. It has a poor survival profile and no optimal treatment is yet defined. We report two HIV-negative, HHV8-positive patients with PEL of the pleural cavity who achieved a durable remission after pleurodesis with bleomycin and no systemic therapy. We also perform a review of the relevant literature regarding the clinical data, treatment, and survival of PEL in HIV-negative patients.
原发性渗出性淋巴瘤（PEL）是一种罕见的非霍奇金淋巴瘤（NHL），主要发生在 HIV 阳性患者中。它的特征是在一个或多个体腔中出现渗出液，没有肿瘤肿块，并且人类疱疹病毒 8 型（HHV8）呈阳性。它的生存情况较差，目前还没有确定最佳的治疗方法。我们报告了 2 例 HIV 阴性、HHV8 阳性的胸腔 PEL 患者，他们在接受博来霉素胸膜固定术后获得了持久缓解，而没有进行全身治疗。我们还对 HIV 阴性患者的 PEL 临床数据、治疗和生存情况进行了文献复习。
