Institute Jules Bordet, Brussels, Belgium.
Curr Opin Oncol. 2010 May;22(3):226-35. doi: 10.1097/CCO.0b013e3283376ac0.
Penile cancer is a rare disease that may cause devastating physical and psychological effects on patients due to the disease itself and/or the associated treatments. As with many other cancer types, significant efforts have been made in penile cancer to minimize invasiveness and morbidity of therapeutic approaches, while aiming to conserve organ function and optimize disease control. This updated review focuses on penile cancer management data published in the last few years.
Several aspects of penile cancer management are discussed in this review. Wider knowledge about the disease's natural history has provided the basis for new TNM staging and follow-up schedule proposals. Modern imaging techniques and gene profiling assays have been applied. A new guideline addressing various aspects of penile cancer was recently published, and more extensive experience has been gained with sentinel lymph node biopsy and radiotherapy. Quality of life and psychosexual impact of the disease are also being addressed.
New diagnostic and therapeutic techniques, as well as attempts to better identify patients who may benefit from less invasive treatments have been studied, but more experience in the field is clearly needed. For this purpose, collaborative multicenter studies are strongly encouraged.
阴茎癌是一种罕见的疾病，由于疾病本身和/或相关治疗，可能会对患者造成毁灭性的身体和心理影响。与许多其他癌症类型一样，人们在阴茎癌治疗方面做出了巨大努力，力求减少治疗方法的侵袭性和发病率，同时保持器官功能并优化疾病控制。本综述重点关注过去几年发表的阴茎癌管理数据。
本综述讨论了阴茎癌管理的几个方面。对疾病自然史的更广泛了解为新的 TNM 分期和随访时间表建议提供了基础。现代影像学技术和基因分析检测已得到应用。最近发布了一个针对阴茎癌各个方面的新指南，并且在淋巴结活检和放疗方面也积累了更多的经验。人们也在关注疾病的生活质量和心理影响。
新的诊断和治疗技术以及试图更好地识别可能从微创治疗中获益的患者的方法已经在研究中，但该领域显然需要更多的经验。为此，强烈鼓励开展合作的多中心研究。
