胰岛素抵抗作为接受透析治疗的慢性肾脏病患者的一个新的治疗靶点。
Insulin resistance as a novel therapeutic target in patients with chronic kidney disease treated with dialysis.
作者信息
Wesołowski Piotr, Saracyn Marek, Nowak Zbigniew, Wańkowicz Zofia
机构信息
Department of Internal Diseases, Military Medicine Institute, Central Hospital, Ministry of National Defence, Warsaw, Poland.
出版信息
Pol Arch Med Wewn. 2010;120(1-2):54-7.
Clinical significance of insulin resistance in patients with chronic renal failure treated with dialysis has not been fully elucidated and requires further research. The available data indicate that long-term dialysis therapy promotes the development of insulin resistance. Furthermore, it has been proven that insulin resistance in this patient group is a strong independent predictor of mortality from cardiovascular causes. Insulin resistance as a potential modifiable cardiovascular risk factor should be considered as a novel therapeutic target in patients undergoing both hemo dialysis and peritoneal dialysis.
透析治疗的慢性肾衰竭患者胰岛素抵抗的临床意义尚未完全阐明，需要进一步研究。现有数据表明，长期透析治疗会促进胰岛素抵抗的发展。此外，已经证实该患者群体中的胰岛素抵抗是心血管疾病死亡的一个强有力的独立预测因素。胰岛素抵抗作为一个潜在的可改变的心血管危险因素，应被视为血液透析和腹膜透析患者的一个新的治疗靶点。
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