Hipmair Gunter, Böhler Nikolaus, Maschek Wilma, Soriguer Federico, Rojo-Martínez Gemma, Schimetta Wolfgang, Pichler Robert
Department of Orthopedics, General Hospital of Linz, Austria.
Neuro Endocrinol Lett. 2010;31(1):155-60.
Clinical data have suggested that obesity protects against osteoporosis. Leptin, mainly secreted by white adipose tissue, might be involved by mediating an effect on bone metabolism. This study was conducted to investigate a possible relationship of leptin and bone turn-over in postmenopausal women with osteoporosis.
We measured bone mineral density (BMD), serum leptin levels and markers of bone metabolism, including osteocalcin and cross-laps in 44 patients with osteoporosis. The main group consisted of 32 postmenopausal women.
Mean serum leptin was 13.1 microg/L and showed no statistically significant difference to the levels measured in a collective of normal persons adjusted for age and BMI. When related to serum cross-laps as markers of bone resorption, a positive correlation (p<0.05) was observed, whereas no correlation with osteocalcin could be seen.
A dual control of bone formation by leptin is assumed: This involves local mechanisms acting on osteoblasts and a central inhibitory effect on bone metabolism via a hypothalamic relay. Our data indicate that the net effect of circulating leptin may cause bone loss and is significantly related to high-turnover serum bone markers, at least in postmenopausal women with osteoporosis.
临床数据表明肥胖可预防骨质疏松症。瘦素主要由白色脂肪组织分泌，可能通过介导对骨代谢的影响而参与其中。本研究旨在探讨绝经后骨质疏松症女性中瘦素与骨转换之间的可能关系。
我们测量了44例骨质疏松症患者的骨密度（BMD）、血清瘦素水平以及骨代谢标志物，包括骨钙素和交联C端肽。主要研究组由32例绝经后女性组成。
血清瘦素平均水平为13.1μg/L，与按年龄和体重指数校正后的正常人群测量值相比，无统计学显著差异。当与作为骨吸收标志物的血清交联C端肽相关时，观察到正相关（p<0.05），而与骨钙素无相关性。
推测瘦素对骨形成有双重控制作用：这涉及作用于成骨细胞的局部机制以及通过下丘脑中继对骨代谢的中枢抑制作用。我们的数据表明，循环瘦素的净效应可能导致骨质流失，并且至少在绝经后骨质疏松症女性中与高转换血清骨标志物显著相关。
