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硬质支气管镜检查联合局部应用丝裂霉素C成功治疗气管狭窄：一例报告

Successful treatment of tracheal stenosis by rigid bronchoscopy and topical mitomycin C: a case report.

作者信息

Wong Jyi Lin, Tie Siew Teck, Samril Bohari, Lum Chee Lun, Rahman Mohammad Rizal Abdul, Rahman Jamalul Azizi Abdul

机构信息

Department of Respiratory Medicine, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia.

出版信息

Cases J. 2010 Jan 4;3:2. doi: 10.1186/1757-1626-3-2.

DOI:10.1186/1757-1626-3-2
PMID:20150982
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2820441/
Abstract

Tracheal stenosis is a known complication of prolonged intubation. It is difficult to treat and traditional surgical approach is associated with significant risk and complications. Recurrent stenosis due to granulation tissue necessitates repeated procedures. We describe a case of short web-like tracheal stenosis (concentric membranous stenosis less than 1 cm in length without associated cartilage damage) managed by a minimally invasive thoracic endoscopic approach. Topical application of Mitomycin C, a potent fibroblast inhibitor reduces granulation tissue formation and prevents recurrence.

摘要

气管狭窄是长期插管已知的并发症。其治疗困难，传统手术方法伴有显著风险和并发症。因肉芽组织导致的复发性狭窄需要反复手术。我们描述了一例采用微创胸段内镜方法治疗的短条索状气管狭窄病例（同心膜状狭窄，长度小于1厘米，无相关软骨损伤）。丝裂霉素C是一种有效的成纤维细胞抑制剂，局部应用可减少肉芽组织形成并防止复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/55f826e53a3e/1757-1626-3-2-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/e515e89c1dee/1757-1626-3-2-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/dbe373715133/1757-1626-3-2-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/fd98c516f519/1757-1626-3-2-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/7a8aff47e962/1757-1626-3-2-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/b1363ae0b626/1757-1626-3-2-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/55f826e53a3e/1757-1626-3-2-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/e515e89c1dee/1757-1626-3-2-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/dbe373715133/1757-1626-3-2-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/fd98c516f519/1757-1626-3-2-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/7a8aff47e962/1757-1626-3-2-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/b1363ae0b626/1757-1626-3-2-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5938/2820441/55f826e53a3e/1757-1626-3-2-6.jpg

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Lesson of the week: tracheal stenosis after intubation.本周病例：插管后气管狭窄
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