Saúde da Mulher e da Criança, Instituto Fernandes Figueira/Fundação Oswaldo Cruz (IFF/Fiocruz), Rio de Janeiro, RJ, Brazil.
J Pediatr (Rio J). 2010 Jan-Feb;86(1):27-32. doi: 10.2223/JPED.1961.
To describe lipid profile, body shape changes, and cardiovascular risk factors in children and adolescents infected with HIV/AIDS receiving highly active antiretroviral therapy.
We investigated 43 children and adolescents being treated with this therapy at the outpatient clinic of pediatric infectious diseases of Instituto Fernandes Figueira/Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. Values of total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were determined. We also performed glucose tolerance test and analyzed body fat distribution, nutritional status, dietary intake, and family history of cardiovascular risk. The statistical analysis was performed using Student's t test. Significance level of p-value was lower than 0.05.
We found lipid abnormality in 88.3% and body shape change in 13.9% of the cases. Nutritional status was adequate (81.3%) in most of the study population. Cholesterol intake in children older than 9 years was above the recommended value.
Prevalence of dyslipidemia and, therefore, risk for cardiovascular diseases were high during the use of highly active antiretroviral therapy.
描述接受高效抗逆转录病毒治疗的感染艾滋病毒/艾滋病的儿童和青少年的血脂谱、体型变化和心血管危险因素。
我们调查了巴西里约热内卢费尔南德斯·菲格伊亚研究所/奥斯瓦尔多·克鲁兹基金会儿科传染病门诊接受这种治疗的 43 名儿童和青少年。测定了总胆固醇、高密度脂蛋白、低密度脂蛋白和甘油三酯的值。我们还进行了葡萄糖耐量试验，并分析了体脂分布、营养状况、饮食摄入和心血管风险的家族史。使用学生 t 检验进行统计分析。p 值的显著性水平低于 0.05。
我们发现 88.3%的病例存在血脂异常，13.9%的病例存在体型变化。大多数研究人群的营养状况良好（81.3%）。9 岁以上儿童的胆固醇摄入量超过了推荐值。
在使用高效抗逆转录病毒治疗期间，血脂异常的发生率很高，因此心血管疾病的风险也很高。
