Papi Luanda, Menezes Ana Carolina G B, Rocha Hélio, Abreu Thalita F, Oliveira Ricardo Hugo de, Frota Ana Cristina C, Evangelista Lucia de A, Hofer Cristina B
Preventive Medicine, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Braz J Infect Dis. 2014 Jul-Aug;18(4):394-9. doi: 10.1016/j.bjid.2013.12.007. Epub 2014 Apr 30.
The aim of present study was to describe the frequency of lipodystrophy syndrome associated with HIV (LSHIV) and factors associated with dyslipidemia in Brazilian HIV infected children. HIV infected children on antiretroviral treatment were evaluated (nutritional assessment, physical examination, and laboratory tests) in this cross-sectional study. Univariate analysis was performed using Mann-Whitney test or Fisher's exact test followed by logistic regression analysis. Presence of dyslipidemia (fasting cholesterol >200mg/dl or triglycerides >130mg/dl) was the dependent variable. 90 children were enrolled. The mean age was 10.6 years (3-16 years), and 52 (58%) were female. LSHIV was detected in 46 children (51%). Factors independently associated with dyslipidemia were: low intake of vegetables/fruits (OR=3.47, 95%CI=1.04-11.55), current use of lopinavir/ritonavir (OR=2.91, 95%CI=1.11-7.67). In conclusion, LSHIV was frequently observed; inadequate dietary intake of sugars and fats, as well as current use of lopinavir/ritonavir was associated with dyslipidemia.
本研究的目的是描述巴西感染艾滋病毒儿童中与艾滋病毒相关的脂肪代谢障碍综合征（LSHIV）的发生率以及与血脂异常相关的因素。在这项横断面研究中，对接受抗逆转录病毒治疗的感染艾滋病毒儿童进行了评估（营养评估、体格检查和实验室检查）。使用曼-惠特尼检验或费舍尔精确检验进行单因素分析，随后进行逻辑回归分析。血脂异常（空腹胆固醇>200mg/dl或甘油三酯>130mg/dl）的存在为因变量。共纳入90名儿童。平均年龄为10.6岁（3至16岁），52名（58%）为女性。46名儿童（51%）检测出LSHIV。与血脂异常独立相关的因素为：蔬菜/水果摄入量低（OR=3.47，95%CI=1.04至11.55），当前使用洛匹那韦/利托那韦（OR=2.91，95%CI=1.11至7.67）。总之，LSHIV经常被观察到；糖和脂肪的饮食摄入不足以及当前使用洛匹那韦/利托那韦与血脂异常有关。
