Department of Biology, McGill University, Montreal, Quebec, Canada.
Dev Dyn. 2010 May;239(5):1365-77. doi: 10.1002/dvdy.22234.
The strengths of the Caenorhabditis elegans model have been recently applied to the study of the pathways of lipid storage, transport, and signaling. As the lipid storage field has recently been reviewed, in this minireview we (1) discuss some recent studies revealing important physiological roles for lipases in mobilizing lipid reserves, (2) describe various pathways of lipid transport, with a particular focus on the roles of lipoproteins, (3) debate the utility of using C. elegans as a model for human dyslipidemias that impinge on atherosclerosis, and (4) describe several systems where lipids affect signaling, highlighting the particular properties of lipids as information-carrying molecules. We conclude that the study of lipid biology in C. elegans exemplifies the advantages afforded by a whole-animal model system where interactions between tissues and organs, and functions such as nutrient absorption, distribution, and storage, as well as reproduction can all be studied simultaneously.
秀丽隐杆线虫模型的优势最近已被应用于脂质储存、运输和信号通路的研究。由于脂质储存领域最近已被综述，在这篇简评中，我们（1）讨论了一些最近的研究，这些研究揭示了脂肪酶在动员脂质储备方面的重要生理作用，（2）描述了各种脂质运输途径，特别关注脂蛋白的作用，（3）争论了使用秀丽隐杆线虫作为影响动脉粥样硬化的人类血脂异常模型的效用，以及（4）描述了几种脂质影响信号转导的系统，突出了脂质作为信息传递分子的特殊性质。我们的结论是，在秀丽隐杆线虫中研究脂质生物学体现了全动物模型系统所带来的优势，在该系统中，可以同时研究组织和器官之间的相互作用以及营养吸收、分布和储存以及生殖等功能。
