[Biochemical markers of vibration effects in workers, and their criterial evaluation].

The authors studied influence of vibration on some serum biochemical values. Oxidative stress and muscular tissue parameters appeared to be the earliest indicators to change. Preclinical stage of vibration disease is characterized by lower activity of superoxide dismutase, increased urinary levels of creatinine and CCr coefficient. Slight increase in serum catalase activity is seen. These parameters increase in vibration disease patients. Urinary creatinine level remains high in some individuals with residual manifestations of vibration disease, after the exposure. Serum levels of copper, ceruloplasmin, potassium, sodium, cholinesterase activity are changed insignificantly under influence of vibration. The authors calculated occurrence of individuals who demonstrate abnormal changes of the stated parameters.