一项针对服用青霉胺时病情复发的类风湿关节炎患者采用硫酸铜辅助治疗的研究。
A study of adjunctive copper sulphate treatment in patients with rheumatoid arthritis who have relapsed while taking D-penicillamine.
作者信息
Pullar T, Wrigley H, Newton K, Toothill C, Wright V
机构信息
Clinical Pharmacology Unit, University of Leeds, The General Infirmary.
出版信息
Br J Clin Pharmacol. 1991 Jan;31(1):105-7. doi: 10.1111/j.1365-2125.1991.tb03866.x.
Formation of a D-penicillamine-copper complex may be necessary for the anti-rheumatic effect of D-penicillamine. Thus, depletion of copper stores by D-penicillamine may eventually lead to relapse in D-penicillamine treated patients. Twenty-one patients who relapsed on D-penicillamine were randomised to copper sulphate 20 mg daily (n = 13) or matched placebo (n = 8) in addition to penicillamine daily for 16 weeks. Urinary copper was increased in the copper treated patients but no statistically significant or clinically important improvement occurred in either group.
D-青霉胺-铜复合物的形成可能是D-青霉胺产生抗风湿作用所必需的。因此，D-青霉胺导致铜储备耗竭最终可能致使接受D-青霉胺治疗的患者病情复发。21例接受D-青霉胺治疗后复发的患者被随机分为两组，一组每天服用20mg硫酸铜（n = 13），另一组每天服用匹配的安慰剂（n = 8），同时两组患者每天均继续服用青霉胺，为期16周。接受铜治疗的患者尿铜增加，但两组均未出现具有统计学意义或临床重要意义的改善。
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