Pullar T, Wrigley H, Newton K, Toothill C, Wright V
Clinical Pharmacology Unit, University of Leeds, The General Infirmary.
Br J Clin Pharmacol. 1991 Jan;31(1):105-7. doi: 10.1111/j.1365-2125.1991.tb03866.x.
Formation of a D-penicillamine-copper complex may be necessary for the anti-rheumatic effect of D-penicillamine. Thus, depletion of copper stores by D-penicillamine may eventually lead to relapse in D-penicillamine treated patients. Twenty-one patients who relapsed on D-penicillamine were randomised to copper sulphate 20 mg daily (n = 13) or matched placebo (n = 8) in addition to penicillamine daily for 16 weeks. Urinary copper was increased in the copper treated patients but no statistically significant or clinically important improvement occurred in either group.
D-青霉胺-铜复合物的形成可能是D-青霉胺产生抗风湿作用所必需的。因此，D-青霉胺导致铜储备耗竭最终可能致使接受D-青霉胺治疗的患者病情复发。21例接受D-青霉胺治疗后复发的患者被随机分为两组，一组每天服用20mg硫酸铜（n = 13），另一组每天服用匹配的安慰剂（n = 8），同时两组患者每天均继续服用青霉胺，为期16周。接受铜治疗的患者尿铜增加，但两组均未出现具有统计学意义或临床重要意义的改善。
