J Rheumatol. 1987 Feb;14(1):67-73.
After a controlled, double blind multicenter trial of D-penicillamine in the treatment of rheumatoid arthritis, 148 patients were followed for an additional year in an open label trial. Complications of longterm D-penicillamine included rash, gastrointestinal manifestations, proteinuria, bone marrow depression, myasthenia gravis, myositis, acute febrile reaction and pemphigus foliaceus. With the exception of one patient with myasthenia gravis, all adverse reactions resolved after withdrawal of D-penicillamine. While the complications of D-penicillamine therapy are usually dose related, these reactions can occur at any time and at any dose. Continued and frequent longterm monitoring of D-penicillamine therapy is required.
在进行了一项关于D-青霉胺治疗类风湿性关节炎的对照双盲多中心试验后，148名患者在一项开放标签试验中又接受了一年的随访。长期使用D-青霉胺的并发症包括皮疹、胃肠道表现、蛋白尿、骨髓抑制、重症肌无力、肌炎、急性发热反应和落叶型天疱疮。除一名重症肌无力患者外，停用D-青霉胺后所有不良反应均消失。虽然D-青霉胺治疗的并发症通常与剂量有关，但这些反应可在任何时间、任何剂量下发生。需要对D-青霉胺治疗进行持续且频繁的长期监测。
