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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Seymour R A, Hawkesford J E, Weldon M, Brewster D

Department of Operative Dentistry, Dental School, Newcastle upon Tyne.

Br J Clin Pharmacol. 1991 Jan;31(1):83-7. doi: 10.1111/j.1365-2125.1991.tb03861.x.

Two separate placebo-controlled studies of parallel design were carried out to evaluate the efficacy of single doses (400 mg) of soluble ibuprofen, ibuprofen liquid in a gelatin capsule and ibuprofen tablets (Nurofen), in patients with postoperative pain after third molar surgery. 2. All ibuprofen preparations provided significant pain relief (P less than 0.05) over a 6 h investigation period. 3. Mean pain scores after ibuprofen tablets and ibuprofen liquid in a gelatin capsule were similar. 4. Soluble ibuprofen 400 mg provided an earlier onset of pain relief (20 min) than ibuprofen tablets (30 min). 5. No unwanted effects were reported in the various ibuprofen treatment groups. 6. The ibuprofen preparations evaluated in this study are effective up to 4 h for controlling postoperative pain after third molar surgery. The soluble form is more efficacious with regard to onset of action.

开展了两项平行设计的、单独的安慰剂对照研究，以评估单剂量（400毫克）可溶性布洛芬、明胶胶囊装布洛芬液剂和布洛芬片（诺洛芬）对第三磨牙手术后患者术后疼痛的疗效。2. 在6小时的研究期间，所有布洛芬制剂均提供了显著的疼痛缓解（P小于0.05）。3. 布洛芬片和明胶胶囊装布洛芬液剂后的平均疼痛评分相似。4. 400毫克可溶性布洛芬比布洛芬片（30分钟）更早开始缓解疼痛（20分钟）。5. 各布洛芬治疗组均未报告不良反应。6. 本研究中评估的布洛芬制剂在控制第三磨牙手术后的术后疼痛方面长达4小时有效。可溶性剂型在起效方面更有效。

Seymour R A, Hawkesford J E, Weldon M, Brewster D

Department of Operative Dentistry, Dental School, Newcastle upon Tyne.

Br J Clin Pharmacol. 1991 Jan;31(1):83-7. doi: 10.1111/j.1365-2125.1991.tb03861.x.

Two separate placebo-controlled studies of parallel design were carried out to evaluate the efficacy of single doses (400 mg) of soluble ibuprofen, ibuprofen liquid in a gelatin capsule and ibuprofen tablets (Nurofen), in patients with postoperative pain after third molar surgery. 2. All ibuprofen preparations provided significant pain relief (P less than 0.05) over a 6 h investigation period. 3. Mean pain scores after ibuprofen tablets and ibuprofen liquid in a gelatin capsule were similar. 4. Soluble ibuprofen 400 mg provided an earlier onset of pain relief (20 min) than ibuprofen tablets (30 min). 5. No unwanted effects were reported in the various ibuprofen treatment groups. 6. The ibuprofen preparations evaluated in this study are effective up to 4 h for controlling postoperative pain after third molar surgery. The soluble form is more efficacious with regard to onset of action.

开展了两项平行设计的、单独的安慰剂对照研究，以评估单剂量（400毫克）可溶性布洛芬、明胶胶囊装布洛芬液剂和布洛芬片（诺洛芬）对第三磨牙手术后患者术后疼痛的疗效。2. 在6小时的研究期间，所有布洛芬制剂均提供了显著的疼痛缓解（P小于0.05）。3. 布洛芬片和明胶胶囊装布洛芬液剂后的平均疼痛评分相似。4. 400毫克可溶性布洛芬比布洛芬片（30分钟）更早开始缓解疼痛（20分钟）。5. 各布洛芬治疗组均未报告不良反应。6. 本研究中评估的布洛芬制剂在控制第三磨牙手术后的术后疼痛方面长达4小时有效。可溶性剂型在起效方面更有效。