Jain A K, Ryan J R, McMahon F G, Kuebel J O, Walters P J, Noveck C
Pharmacotherapy. 1986 Nov-Dec;6(6):318-22. doi: 10.1002/j.1875-9114.1986.tb03494.x.
A single-dose, double-blind, randomized, parallel trial was conducted to compare the analgesic efficacy of oral ibuprofen (I) 100, 200, or 400 mg, aspirin (ASA) 650 mg, and placebo in moderate to severe pain after extraction of impacted teeth. Subjective, self-evaluated pain intensity and pain relief reports, hourly for 6 hours, were used as indexes of analgesic response. Data on 227 evaluable patients showed significant differences among the 4 active treatments and placebo (p less than 0.001) by most measurements of analgesia. Although no consistent, significant differences were observed among the active drugs, I 400 mg performed the best, followed by I 200 mg, ASA 650 mg, and I 100 mg. Remedication was required by 59% patients receiving I 400 mg, 67% taking I 200 mg, 73% taking ASA 650 mg, 74% taking I 100 mg, and 96% receiving placebo. Differences between I 400 mg and I 100 mg were significant for remedication data (p less than 0.05). Side effects were minor, infrequent, and not dose related. In this study, I 100 mg was distinctly superior to placebo and probably as effective as ASA 650 mg in relieving pain. Only a shallow dose response of ibuprofen was observed.
进行了一项单剂量、双盲、随机、平行试验，以比较口服布洛芬（I）100毫克、200毫克或400毫克、阿司匹林（ASA）650毫克和安慰剂对阻生齿拔除术后中度至重度疼痛的镇痛效果。以主观的自我评估疼痛强度和疼痛缓解报告（每小时记录一次，共6小时）作为镇痛反应指标。对227例可评估患者的数据进行分析，通过大多数镇痛测量指标发现，4种活性治疗药物与安慰剂之间存在显著差异（p<0.001）。虽然活性药物之间未观察到一致的显著差异，但400毫克的布洛芬效果最佳，其次是200毫克的布洛芬、650毫克的阿司匹林和100毫克的布洛芬。接受400毫克布洛芬的患者中有59%需要再次用药，服用200毫克布洛芬的患者中有67%，服用650毫克阿司匹林的患者中有73%，服用100毫克布洛芬的患者中有74%，接受安慰剂的患者中有96%。400毫克布洛芬和100毫克布洛芬在再次用药数据方面存在显著差异（p<0.05）。副作用轻微、不常见且与剂量无关。在本研究中，100毫克的布洛芬明显优于安慰剂，在缓解疼痛方面可能与650毫克的阿司匹林效果相当。仅观察到布洛芬有较浅的剂量反应。
