Stehbens W E, Martin B J, Delahunt B
Department of Pathology, Wellington School of Medicine, New Zealand.
Int J Exp Pathol. 1991 Apr;72(2):183-93.
Experimental arterial forks were fashioned by anastomosing one common carotid artery to the contralateral vessel by microvascular surgery in rabbits. In one rabbit group the forks were examined histologically by the serial section technique from 5.5 to 25 months postoperatively. The second group was used for scanning electron microscopy of the arterial endothelial surface from 1 to 257 days post-operatively. Intimal proliferation was observed at the lateral angles histologically at sites comparable to those where intimal proliferation occurs spontaneously in human infants. In addition, disruption of the internal elastic lamina with minimal intimal proliferation occurred at the sides of the neo-apex, mostly in the transposed artery. These disruptions corresponded to predominantly transversely orientated tears of the internal elastic lamina from 8 days post-operatively in the scanning electron microscopic study. They were similar to the early atrophic changes preceding berry aneurysm formation in human cerebral arterial forks. The results indicate that both intimal pads (cushions) and elastic tears can be haemodynamically induced.
通过微血管手术将一只家兔的颈总动脉与对侧血管吻合，制作实验性动脉分叉模型。在一组家兔中，术后5.5至25个月采用连续切片技术对分叉处进行组织学检查。第二组用于术后1至257天对动脉内皮表面进行扫描电子显微镜检查。组织学观察发现，在与人类婴儿自发发生内膜增生部位相当的外侧角处出现了内膜增生。此外，在新顶端两侧出现了内弹性膜破坏且内膜增生轻微的情况，主要发生在移位动脉中。在扫描电子显微镜研究中，这些破坏对应于术后8天起内弹性膜主要呈横向的撕裂。它们类似于人类脑动脉分叉处浆果样动脉瘤形成之前的早期萎缩性变化。结果表明，内膜垫（衬垫）和弹性撕裂均可由血流动力学诱导产生。
