Allergy Unit, Azienda Ospedaliero-Universitaria A.Meyer, Florence, Italy.
Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1 Suppl):61-6.
Nasal topical steroids (INCSs) are well established effective therapy in allergic rhinitis both in children and adults. There is clear benefit in using INCSs over antihistamines in allergic rhinitis while short courses of oral corticosteroids (CSs) may be indicated in severe cases. The addition of INCSs to oral antibiotics has been proven to be more effective than antibiotics alone for achieving symptomatic improvement in patients with acute rhino sinusitis. INCSs as monotherapy are also effective in the treatment of allergic rhinosinusitis (ARS). Several randomized controlled trials have evaluated the role of INCSs in chronic RS with the majority demonstrating a beneficial effect. In adults, the clinical efficacy of oral corticosteroids in the management of chronic RS with nasal polyposis is well established. There are no randomized controlled trials evaluating the efficacy of systemic CSs in chronic RS without nasal polyposis.
鼻腔局部类固醇（INCSs）是治疗儿童和成人变应性鼻炎的有效疗法。在变应性鼻炎中，INCSs 比抗组胺药更有效，而短期口服皮质类固醇（CSs）可能对严重病例有指示作用。已经证明，在急性鼻鼻窦炎患者中，将 INCSs 添加到口服抗生素中比单独使用抗生素更能有效改善症状。INCSs 作为单一疗法也可有效治疗变应性鼻鼻窦炎（ARS）。几项随机对照试验评估了 INCSs 在慢性 RS 中的作用，大多数试验表明有有益的效果。在成年人中，口服皮质类固醇治疗伴有鼻息肉的慢性 RS 的临床疗效已得到充分证实。没有随机对照试验评估全身 CSs 在没有鼻息肉的慢性 RS 中的疗效。
