血管周细胞和内皮细胞的舞蹈：大脑对免疫信号反应的机制。
The dance of the perivascular and endothelial cells: mechanisms of brain response to immune signaling.
机构信息
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
出版信息
Neuron. 2010 Jan 14;65(1):4-6. doi: 10.1016/j.neuron.2009.12.029.
PMID:20152108
Abstract
The mechanisms underlying the brain response to systemic inflammation remain unclear. In this issue of Neuron, Serrats and colleagues demonstrate that two cell types that produce prostaglandins that act on the brain, perivascular and endothelial cells, have an unexpectedly complex interaction in regulating the timing and types of brain responses that occur.
摘要
系统性炎症引起大脑反应的机制尚不清楚。在本期《神经元》杂志上，Serrats 及其同事表明，两种产生作用于大脑的前列腺素的细胞类型——血管周细胞和内皮细胞——在调节发生的大脑反应的时间和类型方面存在着出人意料的复杂相互作用。
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