细胞因子与大脑兴奋性。
Cytokines and brain excitability.
机构信息
Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Health Sciences Centre, 3330 Hospital Dr. NW, Calgary, Alberta, Canada T2N 4N1.
出版信息
Front Neuroendocrinol. 2012 Jan;33(1):116-25. doi: 10.1016/j.yfrne.2011.12.002. Epub 2011 Dec 27.
Abstract
Cytokines are molecules secreted by peripheral immune cells, microglia, astrocytes and neurons in the central nervous system. Peripheral or central inflammation is characterized by an upregulation of cytokines and their receptors in the brain. Emerging evidence indicates that pro-inflammatory cytokines modulate brain excitability. Findings from both the clinical literature and from in vivo and in vitro laboratory studies suggest that cytokines can increase seizure susceptibility and may be involved in epileptogenesis. Cellular mechanisms that underlie these effects include upregulation of excitatory glutamatergic transmission and downregulation of inhibitory GABAergic transmission.
摘要
细胞因子是由外周免疫细胞、小胶质细胞、星形胶质细胞和中枢神经系统中的神经元分泌的分子。外周或中枢炎症的特征是大脑中细胞因子及其受体的上调。新出现的证据表明，促炎细胞因子调节大脑兴奋性。来自临床文献以及体内和体外实验室研究的发现表明，细胞因子可以增加癫痫发作的易感性，并可能参与癫痫发生。这些作用的细胞机制包括兴奋性谷氨酸能传递的上调和抑制性 GABA 能传递的下调。
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