为什么 CD8+ T 细胞在成长过程中需要多样性。

Why CD8+ T cells need diversity when growing up.

机构信息

Center for Immunology, University of Minnesota, Minneapolis, MN 55414, USA.

出版信息

Immunity. 2010 Jan 29;32(1):5-6. doi: 10.1016/j.immuni.2010.01.005.

DOI:10.1016/j.immuni.2010.01.005

PMID:20152164

Abstract

A thymus-specific subunit of the proteasome, beta5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that beta5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.

摘要

先前曾有研究描述并证实了蛋白酶体的胸腺特异性亚基β5t 对于 CD8+ T 细胞的阳性选择是必需的。在本期《免疫》杂志中，Nitta 等人（2010）认为β5t 之所以是必需的，是因为它改变了皮质上皮细胞所呈现的特定肽-MHC 复合物。