Center for Immunology, University of Minnesota, Minneapolis, MN 55414, USA.
Immunity. 2010 Jan 29;32(1):5-6. doi: 10.1016/j.immuni.2010.01.005.
A thymus-specific subunit of the proteasome, beta5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that beta5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.
先前曾有研究描述并证实了蛋白酶体的胸腺特异性亚基β5t 对于 CD8+ T 细胞的阳性选择是必需的。在本期《免疫》杂志中，Nitta 等人（2010）认为β5t 之所以是必需的，是因为它改变了皮质上皮细胞所呈现的特定肽-MHC 复合物。
