CD4+ T 细胞可塑性——Th2 细胞加入人群。
CD4+ T cell plasticity-Th2 cells join the crowd.
机构信息
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Immunity. 2010 Jan 29;32(1):11-3. doi: 10.1016/j.immuni.2010.01.001.
Abstract
In this issue of Immunity, Hegazy et al. (2010) report that in response to lymphocytic choriomeningitis virus (LCMV) infection, fully differentiated virus-specific Th2 cells can be reprogrammed into GATA-3(+)T-bet(+) cells capable of producing both interleukin-4 and interferon-gamma.
摘要
在本期《免疫》中，Hegazy 等人（2010）报告称，在淋巴细胞脉络丛脑膜炎病毒（LCMV）感染后，完全分化的病毒特异性 Th2 细胞可被重新编程为 GATA-3(+)T-bet(+)细胞，能够同时产生白细胞介素-4 和干扰素-γ。
相似文献
1
CD4+ T cell plasticity-Th2 cells join the crowd.CD4+ T 细胞可塑性——Th2 细胞加入人群。
Immunity. 2010 Jan 29;32(1):11-3. doi: 10.1016/j.immuni.2010.01.001.
2
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.干扰素直接诱导 Th2 细胞重编程，产生具有 Th2 和 Th1 细胞功能的稳定 GATA-3(+)T-bet(+)细胞亚群。
Immunity. 2010 Jan 29;32(1):116-28. doi: 10.1016/j.immuni.2009.12.004. Epub 2010 Jan 14.
3
4
Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection.急性淋巴细胞性脉络丛脑膜炎病毒感染后的长期CD4 Th1和Th2记忆
J Virol. 1998 Oct;72(10):8281-8. doi: 10.1128/JVI.72.10.8281-8288.1998.
5
CD4+ Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene.CD4+ Th2 细胞通过删除单个细胞因子 IL-6 和 IL-10 基因，与效应性 Tr1 和 Th1 细胞发挥相似功能。
Mol Immunol. 2012 Jun;51(2):143-9. doi: 10.1016/j.molimm.2012.02.120. Epub 2012 Mar 17.
6
Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.在转基因小鼠中强制表达GATA-3可抑制Th1分化，并在体内诱导形成表达T1/ST2的Th2定向T细胞区室。
J Immunol. 2001 Jul 15;167(2):724-32. doi: 10.4049/jimmunol.167.2.724.
7
'All things considered': transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation.“总而言之”：从前体细胞到效应激活的 T 辅助型 2 细胞分化的转录调控。
Immunology. 2013 Sep;140(1):31-8. doi: 10.1111/imm.12121.
8
Stability of Th1 and Th2 populations.辅助性T细胞1（Th1）和辅助性T细胞2（Th2）群体的稳定性
Int Immunol. 1995 May;7(5):869-75. doi: 10.1093/intimm/7.5.869.
9
Altered Th1 cell differentiation programming by CIITA deficiency.CIITA缺陷导致Th1细胞分化程序改变。
J Immunol. 2004 Nov 1;173(9):5501-8. doi: 10.4049/jimmunol.173.9.5501.
10
Germinal centers regulate human Th2 development.生发中心调节人类Th2细胞的发育。
J Immunol. 2003 Aug 15;171(4):1657-66. doi: 10.4049/jimmunol.171.4.1657.
引用本文的文献
1
Plasticity and lineage commitment of individual T1 cells are determined by stable T-bet expression quantities.单个 T1 细胞的可塑性和谱系决定由稳定的 T-bet 表达量决定。
Sci Adv. 2024 Jun 7;10(23):eadk2693. doi: 10.1126/sciadv.adk2693. Epub 2024 Jun 5.
2
Cluster of differentiation antigens: essential roles in the identification of teleost fish T lymphocytes.分化抗原簇：在硬骨鱼T淋巴细胞识别中的重要作用。
Mar Life Sci Technol. 2022 Aug 19;4(3):303-316. doi: 10.1007/s42995-022-00136-z. eCollection 2022 Aug.
3
Platelet and Megakaryocyte Roles in Innate and Adaptive Immunity.血小板和巨核细胞在固有和适应性免疫中的作用。
Circ Res. 2022 Jan 21;130(2):288-308. doi: 10.1161/CIRCRESAHA.121.319821. Epub 2022 Jan 20.
4
Identification and Characterization of a Master Transcription Factor of Th1 Cells, T-bet, Within Flounder ().鉴定和描述牙鲆（）Th1 细胞的主转录因子 T-bet
Front Immunol. 2021 Jun 28;12:704324. doi: 10.3389/fimmu.2021.704324. eCollection 2021.
5
Kinetics of T lymphocyte subsets and B lymphocytes in response to immunostimulants in flounder (Paralichthys olivaceus): implications for CD4 T lymphocyte differentiation.牙鲆（Paralichthys olivaceus）对免疫刺激剂的 T 淋巴细胞亚群和 B 淋巴细胞的反应动力学：对 CD4 T 淋巴细胞分化的影响。
Sci Rep. 2020 Aug 14;10(1):13827. doi: 10.1038/s41598-020-69542-6.
6
Trogocytosis-Mediated Intracellular Signaling in CD4 T Cells Drives T2-Associated Effector Cytokine Production and Differentiation.细胞触突作用介导的 CD4 T 细胞内信号转导促进 T2 相关效应细胞因子的产生和分化。
J Immunol. 2019 May 15;202(10):2873-2887. doi: 10.4049/jimmunol.1801577. Epub 2019 Apr 8.
7
Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4 T cells.PIK3CD 的激活突变会破坏人类和小鼠 CD4 T 细胞的分化和功能。
J Allergy Clin Immunol. 2019 Jul;144(1):236-253. doi: 10.1016/j.jaci.2019.01.033. Epub 2019 Feb 6.
8
Effector/memory CD4 T cells making either Th1 or Th2 cytokines commonly co-express T-bet and GATA-3.产生Th1或Th2细胞因子的效应/记忆CD4 T细胞通常共表达T-bet和GATA-3。
PLoS One. 2017 Oct 31;12(10):e0185932. doi: 10.1371/journal.pone.0185932. eCollection 2017.
9
Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells.强直性LAT-HDAC7信号维持Nur77和Irf4表达以调节初始CD4 T细胞。
Cell Rep. 2017 May 23;19(8):1558-1571. doi: 10.1016/j.celrep.2017.04.076.
10
Cinnamon ameliorates experimental allergic encephalomyelitis in mice via regulatory T cells: implications for multiple sclerosis therapy.肉桂通过调节性T细胞改善小鼠实验性自身免疫性脑脊髓炎：对多发性硬化症治疗的启示。
PLoS One. 2015 Jan 8;10(1):e0116566. doi: 10.1371/journal.pone.0116566. eCollection 2015.
本文引用的文献
1
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.干扰素直接诱导 Th2 细胞重编程，产生具有 Th2 和 Th1 细胞功能的稳定 GATA-3(+)T-bet(+)细胞亚群。
Immunity. 2010 Jan 29;32(1):116-28. doi: 10.1016/j.immuni.2009.12.004. Epub 2010 Jan 14.
2
Plasticity of CD4+ T cell lineage differentiation.CD4+ T细胞谱系分化的可塑性。
Immunity. 2009 May;30(5):646-55. doi: 10.1016/j.immuni.2009.05.001.
3
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.转录因子T-bet在1型炎症期间控制调节性T细胞的稳态和功能。
Nat Immunol. 2009 Jun;10(6):595-602. doi: 10.1038/ni.1731. Epub 2009 May 3.
4
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells.H3K4me3和H3K27me3的全基因组图谱揭示了分化中的CD4+ T细胞谱系命运决定的特异性和可塑性。
Immunity. 2009 Jan 16;30(1):155-67. doi: 10.1016/j.immuni.2008.12.009.
5
Late developmental plasticity in the T helper 17 lineage.辅助性T细胞17谱系中的晚期发育可塑性。
Immunity. 2009 Jan 16;30(1):92-107. doi: 10.1016/j.immuni.2008.11.005.
6
CD4 T cells: fates, functions, and faults.CD4 T细胞：命运、功能与缺陷
Blood. 2008 Sep 1;112(5):1557-69. doi: 10.1182/blood-2008-05-078154.
7
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function.转化生长因子β诱导的Foxp3通过拮抗RORγt功能抑制辅助性T细胞17分化。
Nature. 2008 May 8;453(7192):236-40. doi: 10.1038/nature06878. Epub 2008 Mar 26.
8
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.辅助性T细胞1型和辅助性T细胞2型：不同的淋巴因子分泌模式导致不同的功能特性。
Annu Rev Immunol. 1989;7:145-73. doi: 10.1146/annurev.iy.07.040189.001045.
Zotero 插件