Hubrecht Institute-KNAW & University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Dev Cell. 2010 Jan 19;18(1):6-7. doi: 10.1016/j.devcel.2010.01.001.
RNAi is essential for pericentromeric heterochromatic formation in S. pombe, and although Dcr1, the initiator protein of this process, has been biochemically well described, its subcellular localization has remained elusive. In this issue of Developmental Cell, Emmerth et al. now show that Dcr1 is dynamically shuttling between nucleus and cytoplasm, adding new insight into the subcellular mechanics of RNAi.
RNAi 对于 S. pombe 着丝粒异染色质的形成至关重要，尽管该过程的起始蛋白 Dcr1 在生化方面已经得到了很好的描述，但它的亚细胞定位仍然难以捉摸。在本期《发育细胞》中，Emmerth 等人现在表明，Dcr1 在核和细胞质之间动态穿梭，为 RNAi 的亚细胞机制提供了新的见解。
