NCI 资助的癌症治疗试验中的健康相关生活质量。

Health related quality of life in NCI-sponsored cancer treatment trials.

机构信息

Head, Palliative Care Research, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA.

出版信息

Semin Oncol Nurs. 2010 Feb;26(1):68-78. doi: 10.1016/j.soncn.2009.11.009.

DOI:10.1016/j.soncn.2009.11.009

PMID:20152580

Abstract

OBJECTIVE

To highlight health related quality of life (HRQOL) measures and published outcomes in phase III clinical trials in the four major cancers: breast, prostate, colorectal, and lung.

DATA SOURCES

Peer-reviewed journals, textbooks, and abstracts published between 1990 and 2009.

CONCLUSION

Over the past 20 years there has been an upsurge in the number and types of HRQOL measures used in phase III cancer treatment trials. Results of trials reported after 2001 indicate a significant increase in specific treatment or disease-related symptom measures in lieu of or as companions to global HRQOL measures. Currently, open NCI-supported trials are incorporating a large number of targeted treatment- and/or disease-related measures.

IMPLICATIONS FOR NURSING PRACTICE

Clinicians can use these data to help patients better understand the spectrum and severity of symptomatic toxicities they will experience with cancer treatment.

摘要

目的

突出在乳腺癌、前列腺癌、结直肠癌和肺癌这四大癌症的 III 期临床试验中与健康相关的生活质量（HRQOL）测量指标和已发表的结果。

资料来源

1990 年至 2009 年间发表的同行评议期刊、教科书和摘要。

结论

在过去的 20 年中，在 III 期癌症治疗试验中使用的 HRQOL 测量指标的数量和类型都有所增加。2001 年后报告的试验结果表明，在全球 HRQOL 测量指标的基础上或作为其补充，特定的治疗或疾病相关症状测量指标显著增加。目前，美国国立癌症研究所（NCI）支持的开放试验正在纳入大量针对治疗和/或疾病相关的测量指标。