花生过敏与哮喘发病率的关系。
Association between peanut allergy and asthma morbidity.
机构信息
Department of Pediatrics, Alfred I. duPont Hospital for Children, Wilmington, DE 19803, USA.
出版信息
J Pediatr. 2010 May;156(5):777-81, 781.e1. doi: 10.1016/j.jpeds.2009.11.080. Epub 2010 Feb 12.
OBJECTIVE
To evaluate the relationship between peanut allergy and asthma morbidity in school-age children.
STUDY DESIGN
The study involved a medical chart review to assess the association of peanut allergy with asthma morbidity in children beyond age 3 years. Peanut allergy was assessed by specific and validated criteria. A Poisson regression model was used to compare the frequency of systemic steroid use and of hospitalization for asthma beyond age 3 years in children with asthma with and without peanut allergy.
RESULTS
Children with peanut allergy had a 2.32-times greater rate of hospitalization (P = .03) and a 1.59-times greater rate of systemic steroid use (P <.001) after controlling for covariates.
CONCLUSIONS
Peanut allergy serves as an early marker for asthma morbidity. Early prevention and intervention can improve quality of care.
目的
评估学龄儿童花生过敏与哮喘发病率之间的关系。
研究设计
本研究通过病历回顾评估了 3 岁以上儿童花生过敏与哮喘发病率之间的关联。通过特定的和经过验证的标准评估花生过敏。采用泊松回归模型比较了哮喘患儿中有无花生过敏与全身类固醇使用和 3 岁以上哮喘住院的频率。
结果
在控制了混杂因素后，花生过敏患儿的住院率（P =.03）和全身类固醇使用率（P <.001）分别增加了 2.32 倍和 1.59 倍。
结论
花生过敏是哮喘发病率的早期标志物。早期预防和干预可以改善医疗质量。
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