Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Cancer Lett. 2010 Jul 28;293(2):207-12. doi: 10.1016/j.canlet.2010.01.017. Epub 2010 Feb 11.
We established a promising new experimental animal model with an orthotopic xenograft of esophageal cancer that successfully represents poor oral intake, a major clinical feature of esophageal cancer. The advantage of this model is that no surgical technique is required, only the injection of a cell suspension by a needle and syringe via the esophageal lumen from the mouth, which provides a high reproducibility of tumor implantation and a rapid progress of outcome. We propose that this model is useful to study cancer-related outcomes and for developing new therapies for esophageal cancer, and we expect it to make a contribution to clinical practice.
我们建立了一个有前景的新的实验动物模型，通过食管腔原位移植食管癌，成功地模拟了食管癌的主要临床特征之一——进食困难。该模型的优点是无需手术技术，只需通过口腔将细胞悬浮液用针和注射器注入食管腔，从而实现了肿瘤植入的高度可重复性和结果的快速进展。我们提出，该模型可用于研究与癌症相关的结果，并开发治疗食管癌的新疗法，我们期望它能为临床实践做出贡献。
