Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Psychiatry Res. 2010 Mar 30;181(3):237-40. doi: 10.1016/j.pscychresns.2009.10.010. Epub 2010 Feb 11.
We reported increased high-energy phosphate metabolism in the basal ganglia of antipsychotic-naïve schizophrenia patients using (31)P Magnetic Resonance Spectroscopy (MRS). These patients were followed up for 1 year and and reassessed using (31)P MRS. Fourteen (8 males) patients with DSM-IV schizophrenia and 14 (11 males) healthy controls underwent (31)P MRS of sub-cortical structures (predominantly basal ganglia) twice (mean+/-S.D. interscan interval 1.15+/-0.17year) on a 1.5T scanner. Total scores on the Positive and Negative Syndrome Scale (PANSS) decreased significantly after treatment in schizophrenia patients. Patients had significantly lower mean PCr/ATP ratios than healthy controls at baseline but not during the follow-up. In patients, there was a significant positive correlation between the magnitude of improvement in PANSS total scores and the extent of change in the PCr/ATP ratio. Findings support the hypothesis that reduction of energy demand or induction of decreased energy-demanding processes might underlie the mechanism of action of antipsychotics in schizophrenia.
我们利用（31）磷磁共振波谱（MRS）报道了未经抗精神病药物治疗的精神分裂症患者基底节高能磷酸代谢增加。这些患者随访了 1 年，并再次使用（31）磷 MRS 进行评估。14 名（8 名男性）DSM-IV 精神分裂症患者和 14 名（11 名男性）健康对照者在 1.5T 扫描仪上进行了两次（皮质下结构（主要是基底节）的（31）磷 MRS（平均+/-S.D. 扫描间隔 1.15+/-0.17 年）。精神分裂症患者在治疗后阳性和阴性综合征量表（PANSS）的总分显著下降。与健康对照组相比，患者在基线时的 PCr/ATP 比值明显较低，但在随访期间没有差异。在患者中，PANSS 总分改善程度与 PCr/ATP 比值变化程度之间存在显著正相关。这些发现支持了这样一种假设，即降低能量需求或诱导降低能量需求的过程可能是抗精神病药物在精神分裂症中的作用机制。
