Migliorelli R, Petracca G, Tesón A, Sabe L, Leiguarda R, Starkstein S E
Department of Behavioral Neurology and Neuropsychiatry, Raúl Carrea Institute of Neurological Research, Buenos Aires, Argentina.
Psychol Med. 1995 May;25(3):505-13. doi: 10.1017/s0033291700033420.
We examined the prevalence, phenomenology, and clinical correlates of delusions in a consecutive series of 103 patients with probable Alzheimer's disease (AD). Patients were examined with the Present State Exam and the Dementia-Psychosis Scale. Twenty-one patients (20%) met DSM-III-R criteria for a delusional disorder. The most frequent delusion type was paranoid (71%), followed by hypochondriacal (67%), the Capgras syndrome (29%), house misidentification (29%), and grandiose delusions (29%). Out of the 21 AD patients with delusions, 76% had three or more different types of delusions simultaneously. The frequency of delusions was not significantly associated with age, education, or age at dementia onset, and the type and severity of cognitive impairments was similar for AD patients with and without delusions. However, AD patients with delusions had significantly higher mania and anosognosia scores.
我们对连续纳入的103例可能患有阿尔茨海默病（AD）的患者进行了妄想的患病率、现象学及临床相关性研究。采用现状检查和痴呆-精神病量表对患者进行检查。21例患者（20%）符合DSM-III-R关于妄想障碍的标准。最常见的妄想类型为偏执型（71%），其次为疑病型（67%）、卡普格拉综合征（29%）、房屋错认（29%）和夸大妄想（29%）。在21例患有妄想的AD患者中，76%同时存在三种或更多不同类型的妄想。妄想的发生频率与年龄、教育程度或痴呆发病年龄无显著相关性，有妄想和无妄想的AD患者认知障碍的类型及严重程度相似。然而，患有妄想的AD患者躁狂和疾病感缺失评分显著更高。
