Department of Hospital Pathology, College of Medicine, the Catholic University of Korea, 150-713 Seoul, Korea.
Hum Pathol. 2010 May;41(5):763-7. doi: 10.1016/j.humpath.2009.05.019. Epub 2010 Feb 12.
Infantile hemangioendothelioma is the most common benign mesenchymal tumor of the liver presenting during the first 6 months of life. Serum alpha fetoprotein is an important tumor marker for hepatoblastoma, hepatocellular carcinoma, and germ cell tumors. However, it is rarely elevated in patients with hepatic infantile hemangioendothelioma. In such cases, surgery may be done to rule out malignancies when alpha fetoprotein levels are high. The etiology of the elevated alpha fetoprotein level has not yet been elucidated. We report 2 cases of solitary hepatic infantile hemangioendothelioma and demonstrate immunohistochemically that hepatocytes near or entrapped within the tumor were the source of the increased serum levels of alpha fetoprotein explaining the unusual clinical presentation.
婴儿型血管内皮细胞瘤是最常见的良性间叶性肝肿瘤，发病于生命的前 6 个月。血清甲胎蛋白是肝母细胞瘤、肝细胞癌和生殖细胞肿瘤的重要肿瘤标志物。然而，在患有肝婴儿型血管内皮细胞瘤的患者中，其水平很少升高。在这种情况下，当甲胎蛋白水平升高时，可能会进行手术以排除恶性肿瘤。升高的甲胎蛋白水平的病因尚未阐明。我们报告了 2 例孤立性肝婴儿型血管内皮细胞瘤，并通过免疫组织化学显示，肿瘤附近或被肿瘤包裹的肝细胞是导致血清甲胎蛋白水平升高的来源，解释了这种不常见的临床表现。
