宿主-微生物相互作用在发育中的斑马鱼中。
Host-microbe interactions in the developing zebrafish.
机构信息
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
出版信息
Curr Opin Immunol. 2010 Feb;22(1):10-9. doi: 10.1016/j.coi.2010.01.006. Epub 2010 Feb 12.
Abstract
The amenability of the zebrafish to in vivo imaging and genetic analysis has fueled expanded use of this vertebrate model to investigate the molecular and cellular foundations of host-microbe relationships. Study of microbial encounters in zebrafish hosts has concentrated on developing embryonic and larval stages, when the advantages of the zebrafish model are maximized. A comprehensive understanding of these host-microbe interactions requires appreciation of the developmental context into which a microbe is introduced, as well as the effects of that microbial challenge on host ontogeny. In this review, we discuss how in vivo imaging and genetic analysis in zebrafish has advanced our knowledge of host-microbe interactions in the context of a developing vertebrate host. We focus on recent insights into immune cell ontogeny and function, commensal microbial relationships in the intestine, and microbial pathogenesis in zebrafish hosts.
摘要
斑马鱼易于进行体内成像和遗传分析，这促使人们更多地将这种脊椎动物模型用于研究宿主-微生物关系的分子和细胞基础。在斑马鱼宿主中研究微生物的遭遇，主要集中在胚胎和幼体发育阶段，此时斑马鱼模型的优势得到了最大化。要全面了解这些宿主-微生物相互作用，需要认识到微生物进入的发育背景，以及这种微生物挑战对宿主发育的影响。在这篇综述中，我们讨论了斑马鱼体内成像和遗传分析如何在发育中的脊椎动物宿主背景下促进我们对宿主-微生物相互作用的认识。我们重点介绍了最近在免疫细胞发生和功能、肠道共生微生物关系以及斑马鱼宿主中的微生物发病机制方面的见解。
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