Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands.
Neurosci Biobehav Rev. 2011 Jan;35(3):356-65. doi: 10.1016/j.neubiorev.2010.02.005. Epub 2010 Feb 12.
In young, typically developing children, repetitive behavior similar to that in certain neuropsychiatric syndromes is common. Whereas this behavior is adaptive in typical development, in many disorders it forms a core component of symptoms and causes prominent impairment in the daily life of affected individuals. Understanding the neurobiological mechanisms involved repetitive behavior will improve our understanding of the pathogenesis of developmental neuropsychiatric disorders, stimulating novel approaches to these conditions. However, studies on the neurobiology of human repetitive behavior have often been limited to distinct conditions and generalization has been hindered by inconsistent terminology. In this paper, we synthesize the 'disorder-driven' literature, building on findings from fundamental animal research and translational models. These findings suggest a model for classifying repetitive behavior by its neuroanatomical correlates.
在年轻、正常发育的儿童中，类似某些神经精神综合征的重复行为很常见。虽然这种行为在典型发育中是适应性的，但在许多疾病中，它构成了症状的核心组成部分，并导致受影响个体的日常生活明显受损。了解涉及重复行为的神经生物学机制将提高我们对发育性神经精神障碍发病机制的理解，从而为这些疾病提供新的治疗方法。然而，人类重复行为的神经生物学研究往往局限于特定的疾病，并且由于术语不一致，推广受到阻碍。在本文中，我们综合了“疾病驱动”的文献，以基础动物研究和转化模型的发现为基础。这些发现为根据神经解剖学相关性对重复行为进行分类提供了一个模型。
