Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands.
Neurosci Biobehav Rev. 2011 Jan;35(3):345-55. doi: 10.1016/j.neubiorev.2010.02.004. Epub 2010 Feb 13.
Repetitive and stereotyped behavior is a prominent element of both animal and human behavior. Similar behavior is seen across species, in diverse neuropsychiatric disorders and in key phases of typical development. This raises the question whether these similar classes of behavior are caused by similar neurobiological mechanisms or whether they are neurobiologically unique? In this paper we discuss fundamental animal research and translational models. Imbalances in corticostriatal function often result in repetitive behavior, where different classes of behavior appear to be supported by similar neural mechanisms. Although the exact nature of these imbalances are not yet fully understood, synthesizing the literature in this area provides a framework for studying the neurobiological systems involved in repetitive behavior.
重复刻板行为是动物和人类行为的一个突出特征。在不同的神经精神障碍和典型发育的关键阶段，都可以看到类似的行为。这就提出了一个问题，即这些相似的行为类别是否是由相似的神经生物学机制引起的，还是它们在神经生物学上是独特的？在本文中，我们讨论了基础动物研究和转化模型。皮质纹状体功能的失衡通常会导致重复行为，而不同类别的行为似乎是由相似的神经机制支持的。尽管这些失衡的确切性质尚不完全清楚，但综合该领域的文献为研究涉及重复行为的神经生物学系统提供了一个框架。
