Arai Ayako, Imadome Ken-Ichi, Fujiwara Shigeyoshi, Miura Osamu
Department of Hematology, Tokyo Medical and Dental University, Tokyo.
Intern Med. 2010;49(4):325-9. doi: 10.2169/internalmedicine.49.2829. Epub 2010 Feb 15.
An 88-year-old man with autoimmune hemolytic anemia (AIHA) who had been treated with low dose prednisolone developed a sudden worsening of his anemia accompanied by reactivation of Epstein-Barr virus (EBV). We established EBV-infected spontaneous lymphoblastoid cell lines (LCL), performed an enzyme-linked immunosorbent spot assay, and confirmed a significantly suppressed EBV-specific cytotoxic T-cell (CTL) response to the LCL. EBV reactivation might have been brought about by suppressed CTL activity which could have been due to low dose PSL administration or aging. Since the EBV-DNA titer decreased as AIHA improved, we concluded that EBV might have played a role in the development of anemia.
一名88岁患有自身免疫性溶血性贫血（AIHA）的男性，曾接受低剂量泼尼松龙治疗，其贫血突然恶化，同时伴有EB病毒（EBV）再激活。我们建立了EBV感染的自发淋巴母细胞系（LCL），进行了酶联免疫斑点试验，并证实对LCL的EBV特异性细胞毒性T细胞（CTL）反应显著受到抑制。EBV再激活可能是由于CTL活性受到抑制所致，这可能是由于低剂量PSL给药或衰老引起的。由于随着AIHA的改善EBV-DNA滴度下降，我们得出结论，EBV可能在贫血的发生中起作用。
