Programa de Pós-graduação em Hematologia, Universidade do Estado do Amazonas, Manaus-Amazonas, Brazil.
Laboratório de Virologia e Imunologia, Coordenação Sociedade, Ambiente e Saúde, Instituto Nacional de Pesquisas da Amazônia (INPA), Manaus-Amazonas, Brazil.
Biomed Res Int. 2020 Oct 24;2020:1627824. doi: 10.1155/2020/1627824. eCollection 2020.
Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections are widely distributed throughout the world. EBV is linked to various hematological and autoimmune disorders whereas CMV might play important role in the progression of chronic hematological diseases, such as hemoglobinopathies, lymphomas, myelomas, hemophilia, and aplastic and sickle cell anemia. Both viruses produce a viral homolog of human interleukin-10 that can cause general suppression of immune response, increasing susceptibility to other infections. These viruses can remain latent in the host cells and be reactivated when the host immune system is compromised. Studies showing the impact of CMV and EBV infections on hematological disorders are scarce and unclear in the context of coinfection. This review intends to present the biology, prevalence, and impact of CMV and EBV infections in patients with hematological diseases.
巨细胞病毒（CMV）和爱泼斯坦-巴尔病毒（EBV）感染广泛分布于世界各地。EBV 与各种血液学和自身免疫性疾病有关，而 CMV 可能在慢性血液系统疾病的进展中发挥重要作用，如血红蛋白病、淋巴瘤、骨髓瘤、血友病、再生障碍性贫血和镰状细胞贫血。这两种病毒都产生人类白细胞介素-10 的病毒同源物，可导致免疫反应普遍抑制，增加对其他感染的易感性。这些病毒可以潜伏在宿主细胞中，并在宿主免疫系统受损时被重新激活。在合并感染的情况下，关于 CMV 和 EBV 感染对血液系统疾病影响的研究很少且不清楚。本综述旨在介绍血液系统疾病患者中 CMV 和 EBV 感染的生物学、流行情况和影响。
