直接抗球蛋白试验C3阳性而IgG阴性的温抗体型自身免疫性溶血性贫血：病例研究及发病率与严重程度的文献分析
Warm Autoimmune Hemolytic Anemia with a Direct Antiglobulin Test Positive for C3 and Negative for IgG: A Case Study and Analytical Literature Review of Incidence and Severity.
作者信息
Palla Amruth R, Khimani Farhad, Craig Michael D
机构信息
Department of Medicine, Integris Southwest Medical Center, Oklahoma City, OK.
出版信息
Clin Med Insights Case Rep. 2013 Apr 2;6:57-60. doi: 10.4137/CCRep.S11469. Print 2013.
Abstract
Polygenic IgG autoantibodies are implicated in majority of the cases of warm autoimmune hemolytic anemia (WAIHA). In some of these cases, complement (C3) proteins accompany the IgG antibodies. WAIHA mediated by C3 alone is relatively rare. We present an interesting case of WAIHA with a direct antiglobulin test (DAT) positive for C3 but negative for IgG in a 79-year-old woman and perform an analytical literature review of the incidence and severity of this clinical entity.
摘要
多基因IgG自身抗体与大多数温抗体型自身免疫性溶血性贫血（WAIHA）病例有关。在其中一些病例中，补体（C3）蛋白与IgG抗体同时存在。仅由C3介导的WAIHA相对少见。我们报告了一例有趣的WAIHA病例，一名79岁女性的直接抗球蛋白试验（DAT）结果显示C3阳性但IgG阴性，并对该临床实体的发病率和严重程度进行了分析性文献综述。
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