Nomura Tsunehisa, Tsunoda Kazuko, Ohta Satoko, Doi Katsumi, Miyoshi Kazuya, Hasegawa Yasuhisa, Mizutani Masami
Dept. of Breast and Thyroid Surgery,National Hospital Organization Fukuyama Medical Center.
Gan To Kagaku Ryoho. 2014 Feb;41(2):221-4.
We evaluated the effect of using the cooling method on pain at the site of luteinizing hormone-releasing hormone(LH-RH) agonist injection in 181 prostate cancer or premenopausal breast cancer patients by using a numerical rating scale(NRS)and a questionnaire survey with open-ended questions. According to the NRS, 38.1% of the patients experienced a reduction in pain, 37.5% experienced no change, and 24.4% experienced an increase in pain. Therefore, use of the cooling method did not have a statistically significant effect in terms of pain reduction(p=0.123). However, on analyzing pain reduction according to the answers in the questionnaire survey, 53.2% of the patients experienced a reduction in pain, 38.5% experienced no change, and 8.3% experienced an increase in pain. These findings were different from those obtained on using the NRS. In addition, irrespective of using the cooling method, needle thickness and patient obesity strongly influenced the pain experienced. The skin icing method was effective in reducing pain at the site of LH-RH agonist injection. This method is simple, inexpensive, and safe, and is hence recommended.
我们采用数字评分量表（NRS）和开放式问卷调查，评估了181例前列腺癌或绝经前乳腺癌患者使用冷却方法对促黄体生成素释放激素（LH-RH）激动剂注射部位疼痛的影响。根据NRS，38.1%的患者疼痛减轻，37.5%的患者疼痛无变化，24.4%的患者疼痛加重。因此，就减轻疼痛而言，使用冷却方法没有统计学上的显著效果（p=0.123）。然而，根据问卷调查的答案分析疼痛减轻情况时，53.2%的患者疼痛减轻，38.5%的患者疼痛无变化，8.3%的患者疼痛加重。这些结果与使用NRS时获得的结果不同。此外，无论是否使用冷却方法，针头粗细和患者肥胖程度对疼痛感受有很大影响。皮肤冰敷法可有效减轻LH-RH激动剂注射部位的疼痛。该方法简单、廉价且安全，因此推荐使用。
