Rogers D, Karki C, Bartlett C, Pocock P
Burden Neurological Hospital, Stapleton, Bristol.
Br J Psychiatry. 1991 Jan;158:97-102. doi: 10.1192/bjp.158.1.97.
Among 236 in-patients in one hospital for the mentally handicapped, there was a significant relationship between the amount of motor disorder (rated using a comprehensive check-list) and the severity of mental handicap, the presence of associated psychiatric disorder and the use of neuroleptic medication. The population was fairly evenly divided between those currently, previously and never having received neuroleptic medication. All categories of motor disorder, including abnormal movements, were present in all three subgroups. Neuroleptic medication appeared to modify the expression of motor disorder rather than producing it de novo. The range and frequency of motor disorders was comparable with that in patients with severe psychiatric illness. A common cerebral basis for the motor disorders of patients with mental handicap and severe psychiatric illness is suggested.
在一家智障患者医院的236名住院患者中,运动障碍程度(使用综合检查表评定)与智力障碍严重程度、相关精神障碍的存在以及抗精神病药物的使用之间存在显著关联。目前、既往和从未接受过抗精神病药物治疗的患者在人群中分布较为均匀。所有三个亚组中均存在各类运动障碍,包括异常运动。抗精神病药物似乎改变了运动障碍的表现形式,而非引发运动障碍。运动障碍的范围和频率与重度精神疾病患者相当。这提示智障患者和重度精神疾病患者的运动障碍存在共同的大脑基础。