Sedgwick D M, Barton J R, Hamer-Hodges D W, Nixon S J, Ferguson A
Gastrointestinal Unit, University of Edinburgh, UK.
Br J Surg. 1991 Feb;78(2):171-5. doi: 10.1002/bjs.1800780212.
A geographically based cohort of 68 children with Crohn's disease was derived by sampling from Scottish Hospital In-patient Statistics. Surgical histories were examined and analysed by actuarial methods, and the nature of major operations performed was compared with operations for Crohn's disease in the Lothians' Surgical Audit. Fifty-four of the 68 patients were treated surgically, with a total of 135 operations (71 major, 64 minor). Fifty per cent of the cohort had a major operation within 5 years of onset of symptoms; median time to a second operation was 4 years. The types of major operation performed in juvenile onset patients differed significantly from those recorded in the Lothians' audit, with a high rate of exploratory laparotomy in younger patients (12 cases). With a mean follow-up of 7 years, 12 patients (18 per cent) have a permanent stoma. There were five deaths, three postoperative. This study highlights the frequency of surgical intervention in young people with Crohn's disease.
从苏格兰医院住院统计数据中抽样，选取了一组68名患有克罗恩病的儿童，他们来自不同地理区域。通过精算方法对手术史进行了检查和分析，并将所进行的主要手术的性质与洛锡安外科审计中克罗恩病手术情况进行了比较。68名患者中有54名接受了手术治疗，总共进行了135次手术（71次大手术，64次小手术）。该队列中有50%的患者在症状出现后5年内进行了大手术；第二次手术的中位时间为4年。青少年发病患者所进行的主要手术类型与洛锡安审计记录的有显著差异，年轻患者中 exploratory laparotomy（剖腹探查术）的比例较高（12例）。平均随访7年，12名患者（18%）有永久性造口。有5例死亡，3例为术后死亡。这项研究突出了克罗恩病青少年患者手术干预的频率。
