Life and Health Sciences Research Institute, University of Minho, Braga, Portugal.
Nat Rev Immunol. 2010 Mar;10(3):170-81. doi: 10.1038/nri2711. Epub 2010 Feb 15.
Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in infection by limiting the immune response to pathogens and thereby preventing damage to the host. Recently, an increasing interest in how IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation. Understanding the specific molecular events that regulate the production of IL-10 will help to answer the remaining questions that are important for the design of new strategies of immune intervention.
白细胞介素-10（IL-10）是一种具有抗炎特性的细胞因子，在感染中起着核心作用，通过限制对病原体的免疫反应，从而防止宿主受损。最近，人们越来越关注 IL10 表达在不同免疫细胞中是如何调控的，这揭示了信号转导、表观遗传学、转录因子结合和基因激活等水平上涉及的一些分子机制。了解调节 IL-10 产生的特定分子事件将有助于回答对于设计新的免疫干预策略仍然重要的剩余问题。
