Department of Psychiatry, Center for Mental Health Policy and Services Research, University of Pennsylvania School of Medicine, 3535 Market Street, Philadelphia, PA 19104, USA.
Aging Ment Health. 2010 Jan;14(1):1-19. doi: 10.1080/13607860903421003.
This systematic review examined the effectiveness of community-based heart-health interventions on depression outcomes among homebound elderly (64 years and older) with heart disease.
A comprehensive literature search and meta analysis was performed to evaluate randomized controlled trials examining outpatient or home-based interventions. Methodological quality was assessed by standard criteria developed by the Cochrane Collaborative Initiative.
Fifteen studies met our inclusion criteria and all measured depression outcomes. Studies differed in scope and methodological rigor and sample sizes varied widely. Problems in treatment fidelity and masking of group assignment were noted. Great variability was found in depression outcomes due to the differences in methodology and intervention. Five studies reported significant treatment effect on depression; three of those employed home-based interventions and two were outpatient-clinic interventions. Ten studies were included in the meta analysis and the effect sizes (ESs) ranged from -0.39 (in favor of control group) to 0.65 (in favor of treatment group). The mean weighted ES was 0.11 and six studies showed positive ESs.
Mixed evidence for community-based heart disease interventions on depression outcomes was found. Future research should include sub-analysis of ESs of interventions on depression outcomes by different demographic characteristics of the study sample, common depression outcome measures, and different follow-up periods.
本系统评价考察了以社区为基础的心脏健康干预措施对患有心脏病的居家老年(64 岁及以上)人群抑郁结局的影响。
采用全面的文献检索和荟萃分析方法,评估了针对门诊或家庭为基础的干预措施的随机对照试验。采用 Cochrane 协作组织制定的标准标准评估方法学质量。
符合纳入标准的研究共有 15 项,均测量了抑郁结局。研究在范围和方法学严谨性以及样本量方面存在差异。在治疗一致性和分组掩蔽方面存在问题。由于方法学和干预措施的差异,抑郁结局存在很大的变异性。五项研究报告了对抑郁有显著的治疗效果;其中三项采用了家庭为基础的干预措施,两项为门诊诊所干预措施。共有 10 项研究纳入荟萃分析,效应量(ES)范围从 -0.39(有利于对照组)到 0.65(有利于治疗组)。加权平均 ES 为 0.11,有 6 项研究显示出阳性 ES。
发现以社区为基础的心脏病干预措施对抑郁结局的证据存在差异。未来的研究应包括根据研究样本的不同人口统计学特征、常见的抑郁结局测量指标以及不同的随访期对干预措施对抑郁结局的 ES 进行亚分析。