Seoul National University, Seoul, South Korea.
Nutr Cancer. 2009;61(6):847-54. doi: 10.1080/01635580903285072.
Inflammatory tissue injury has been implicated in tumor promotion and progression. 3,5,4'-trihydroxy-trans-stilbene (resveratrol) and 3,4,3', 5'-tetrahydroxy-trans-stilbene (piceatannol), 2 structurally related plant polyphenols, have been reported to possess antioxidant, anti-inflammatory, and chemopreventive properties. This study was aimed at investigating the possible protective effects of resveratrol and piceatannol against dextran sulfate sodium (DSS)-induced inflammation in mouse colonic mucosa. Administration of DSS (2.5%) in drinking water for 7 days to male ICR mice resulted in colitis and elevated expression of inducible nitric oxide synthase (iNOS) and activation of nuclear factor-kappa B (NF-kappaB), a major transcription factor known to upregulate proinflammatory gene expression. Phosphorylation of extracellular signal-regulated kinase (ERK) and signal transducer and activator of transcription-3 (STAT3) was also enhanced after DSS treatment. Oral administration of resveratrol or piceatannol (10 mg/kg body weight each) for 7 constitutive days attenuated the DSS-induced inflammatory injury, upregulation of iNOS expression, and activation of NF-kappaB, STAT3, and ERK.
炎症组织损伤与肿瘤的促进和进展有关。3,5,4'-三羟基反式-二苯乙烯（白藜芦醇）和 3,4,3',5'-四羟基反式-二苯乙烯（白皮杉醇），这两种结构相关的植物多酚，据报道具有抗氧化、抗炎和化学预防特性。本研究旨在研究白藜芦醇和白皮杉醇对葡聚糖硫酸钠（DSS）诱导的小鼠结肠黏膜炎症的可能保护作用。在雄性 ICR 小鼠饮用水中添加 2.5%的 DSS 7 天，导致结肠炎和诱导型一氧化氮合酶（iNOS）的表达升高，以及核因子-κB（NF-κB）的激活，NF-κB 是一种已知上调促炎基因表达的主要转录因子。DSS 处理后，细胞外信号调节激酶（ERK）和信号转导和转录激活因子 3（STAT3）的磷酸化也增强。连续 7 天口服白藜芦醇或白皮杉醇（各 10mg/kg 体重）可减轻 DSS 诱导的炎症损伤、iNOS 表达上调以及 NF-κB、STAT3 和 ERK 的激活。
