Tufts University, Boston, Massachusetts 02111, USA.
Nutr Cancer. 2009;61(6):875-8. doi: 10.1080/01635580903285197.
Protection by vitamin E against free radical-induced DNA mutations appears not to be an effective occurrence. On the other hand, in vitro evidence that different tocopherols slow down cell proliferation is an accepted observation. However, such an event may not be sufficient to result in beneficial clinical outcomes. Tocopheryl phosphate, a more active, natural derivative of tocopherol, endowed with prevention and therapeutic potential, represents a possible key to the understanding of the present conflict between laboratory and clinical results.
维生素 E 对自由基诱导的 DNA 突变的保护作用似乎并不明显。另一方面，体外证据表明不同的生育酚会减缓细胞增殖，这是一个被接受的观察结果。然而，这种情况可能不足以导致有益的临床结果。生育酚磷酸盐，一种更活跃的、天然的生育酚衍生物，具有预防和治疗的潜力，它可能是理解实验室和临床结果之间目前冲突的关键。
